The anti-allergic effects of Crinum glaucum aqueous extract

被引：18
|
作者：
Okpo, SO [1 ]
Adeyemi, OO [1 ]
机构：
[1] Univ Lagos, Dept Pharmacol, Coll Med, PMB, Lagos 12003, Nigeria
来源：
PHYTOMEDICINE | 2002年 / 9卷 / 05期
关键词：
Crinum glaucum; anti-allergic; passive cutaneous anaphylaxis; bronchoconstriction;
D O I：
10.1078/09447110260571698
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
The aqueous extract of Crinum glaucum was investigated for its effects on rat passive cutaneous anaphylactic reaction, rat peritoneal mast cell degranulation and allergic bronchoconstriction in the guinea pig. The extract demonstrated a significant (p < 0.05) reduction in area of dye leakage. The extract, administered for five days, inhibited mast cell degranulation of normal and passively sensitized rats induced by dextran and antigen. Allergic bronchoconstriction in actively sensitized guinea pigs was inhibited by the extract. The effects of the extract observed were comparable to those of sodium cromoglycate. These results substantiate the efficacy of the extract in the treatment of asthma, in traditional medicine.
引用
收藏
页码：438 / 441
页数：4
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