Nuclear NFATc1 Causes Development of Fms-like Receptor Tyrosine Kinase 3 Receptor (FLT3) Internal Tandem Duplication Mutation-Positive (FLT3-ITD) Acute Myeloid Leukemia (AML) and Mediates Drug Resistance

被引：1
|
作者：
Solovey, Maria A. [1 ]
Wang, Ying [1 ]
Gattenloehner, Stefan [2 ]
Hessmann, Elisabeth [3 ]
Metzelder, Stephan [1 ]
Michel, Christian [1 ]
Ellenrieder, Volker [3 ]
Goethert, Joachim R. [4 ]
Neubauer, Andreas [1 ,5 ]
Burchert, Andreas [1 ]
机构：
[1] Univ Hosp Giessen & Marburg, Dept Hematol & Oncol, Marburg, Germany
[2] Univ Hosp Giessen, Dept Pathol, Giessen, Germany
[3] Univ Hosp Gottingen, Dept Gastroenterol, Gottingen, Germany
[4] Univ Hosp Essen, West German Canc Ctr, Dept Hematol, Essen, Germany
[5] Univ Giessen & Marburg, Med Ctr, Univ Marburg, Dept Internal Med & Hematol Oncol & Immunol, Marburg, Germany
来源：
BLOOD | 2016年 / 128卷 / 22期
关键词：
D O I：
10.1182/blood.V128.22.1722.1722
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
1722
引用
收藏
页数：5
相关论文
共 50 条
  • [21] Quantum-First: Safety By Treatment Phase and By Age in Newly Diagnosed (nd) Patients (pts) with FMS-like Tyrosine Kinase 3-Internal Tandem Duplication ( FLT3-ITD) Positive Acute Myeloid Leukemia (AML)
    Erba, Harry P.
    Dombret, Herve
    Perl, Alexander
    Mitov, Tsvetomir
    Liu, Li
    Kamel, Yasser Mostafa
    Imadalou, Karima
    Choi, Youngsook
    Levis, Mark J.
    Schlenk, Richard F.
    BLOOD, 2023, 142
  • [22] Mutation topography and risk stratification for de novo acute myeloid leukaemia with normal cytogenetics and no nucleophosmin 1 (NPM1) mutation or Fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD)
    Zhou, Ya-Lan
    Wu, Li-Xin
    Gale, Robert Peter
    Wang, Zi-Long
    Li, Jin-Lan
    Jiang, Hao
    Jiang, Qian
    Jiang, Bin
    Cao, Shan-Bo
    Lou, Feng
    Sun, Ying
    Wang, Cheng-Cheng
    Liu, Yan-Rong
    Wang, Yu
    Chang, Ying-Jun
    Xu, Lan-Ping
    Zhang, Xiao-Hui
    Liu, Kai-Yan
    Ruan, Guo-Rui
    Huang, Xiao-Jun
    BRITISH JOURNAL OF HAEMATOLOGY, 2020, 190 (02) : 274 - 283
  • [23] The Pim kinase inhibitor AZD1208 sensitizes acute myeloid leukemia cells with fms-like tyrosine kinase 3 internal tandem duplication (FLT3-ITD) to cytotoxic effects of chemotherapy drugs
    Doshi, Kshama A.
    Natarajan, Karthika
    Wolfson, Benjamin
    Huszar, Dennis
    Baer, Maria R.
    CANCER RESEARCH, 2015, 75
  • [24] High fms-like tyrosine kinase-3 (FLT3) receptor surface expression predicts poor outcome in FLT3 internal tandem duplication (ITD) negative patients in adult acute myeloid leukaemia: a prospective pilot study from India
    Sharawat, Surender Kumar
    Raina, Vinod
    Kumar, Lalit
    Sharma, Atul
    Bakhshi, Radhika
    Vishnubhatla, Sreenivas
    Gupta, Ritu
    Bakhshi, Sameer
    INDIAN JOURNAL OF MEDICAL RESEARCH, 2016, 143 : 11 - 16
  • [25] Sorafenib in Relapsed AML With FMS-Like Receptor Tyrosine Kinase-3 Internal Tandem Duplication Mutation
    Giri, Smith
    Hamdeh, Shadi
    Bhatt, Vijaya Raj
    Schwarz, James K.
    JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2015, 13 (05): : 508 - 514
  • [26] Sorafenib for refractory FMS-like tyrosine kinase receptor-3 (FLT3/ITD+) acute myeloid leukemia after allogenic stem cell transplantation
    Sora, Federica
    Chiusolo, Patrizia
    Metafuni, Elisabetta
    Bellesi, Silvia
    Giammarco, Sabrina
    Laurenti, Luca
    Ausoni, Giuseppe
    Zini, Gina
    Bayer, Alina J.
    Mario, Balducci
    Leone, Giuseppe
    Sica, Simona
    LEUKEMIA RESEARCH, 2011, 35 (03) : 422 - 423
  • [27] Evaluation of FMS like tyrosine kinase 3(FLT3) internal tandem duplication and D835 mutation exon 17 in acute myeloid leukemia and acute promyelocytic leukemia
    Culurgioni, F.
    Lilliu, S.
    Pala, G.
    Cardia, D.
    Pilloni, C.
    Piras, D.
    Angelucci, E.
    HAEMATOLOGICA-THE HEMATOLOGY JOURNAL, 2007, 92 : 73 - 74
  • [28] Cabozantinib is selectively cytotoxic in acute myeloid leukemia cells with FLT3-internal tandem duplication (FLT3-ITD)
    Lu, Jeng-Wei
    Wang, An-Ni
    Liao, Heng-An
    Chen, Chien-Yuan
    Hou, Hsin-An
    Hu, Chung-Yi
    Tien, Hwei-Fan
    Ou, Da-Liang
    Lin, Liang-In
    CANCER LETTERS, 2016, 376 (02) : 218 - 225
  • [29] Quantum-First: Deep-Dive Analysis of FMS-like Tyrosine Kinase 3-Internal Tandem Duplication (FLT3-ITD) Detection Methods Utilized for Enrollment and Longitudinal MRD Detection in Newly Diagnosed (nd) Patients (pts) with FLT3-ITD-Positive (FLT3-ITD+) Acute Myeloid Leukemia (AML)
    Rohrbach, Jaime E. Connolly
    Waldron, Edward
    Liu, Li
    Rivera, Shawn
    Subramanya, Sridevi Kayyur
    Abraham, Violet
    Perl, Alexander E.
    Levis, Mark J.
    BLOOD, 2024, 144 : 4279 - 4279
  • [30] Internal Tandem Duplication (ITD) in the Tyrosine Kinase Domain of FLT3 Displays Higher Oncogenic Potential in Acute Myeloid Leukemia
    Marhall, Alissa
    Fischer, Thomas
    Heidel, Florian H.
    Kazi, Julhash U.
    Ronnstrand, Lars
    BLOOD, 2016, 128 (22)
12345