Synthesis of 2′-C-β-Methyl-2′-deoxyguanosine

被引：5
|
作者：
Li, Nan-Sheng [1 ]
Lu, Jun
Piccirilli, Joseph A.
机构：
[1] Univ Chicago, Howard Hughes Med Inst, Dept Biochem & Mol Biol, Chicago, IL 60637 USA
来源：
JOURNAL OF ORGANIC CHEMISTRY | 2009年 / 74卷 / 05期
关键词：
HEPATITIS-C-VIRUS; SUGAR PYRIMIDINE NUCLEOSIDES; ADENOSINE RECEPTOR AGONISTS; ACID RELATED-COMPOUNDS; RADICAL DEOXYGENATION; SECONDARY ALCOHOLS; ANTIVIRAL ACTIVITY; RNA REPLICATION; TERT-ALCOHOLS; RIBONUCLEOSIDES;
D O I：
10.1021/jo802666k
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We describe two approaches for the synthesis of 2'-C-beta-methyl-2'-deoxyguanosine (3) via 2'-radical deoxygenation. One approach starts from 1,3,5-tri-O-benzoyl-alpha-D-ribofuranose (6) and gives 3 in 11 steps with 9.7% overall yield. The second approach starts from guanosine and gives 3 in 8 steps with 23% overall yield.
引用
收藏
页码：2227 / 2230
页数：4
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