Effect of 2% dorzolamide on retinal blood flow: a study on juvenile primary open-angle glaucoma patients already receiving 0.5% timolol

被引：15
|
作者：
Costagliola, Ciro [1 ]
Campa, Claudio [1 ]
Parmeggiani, Francesco [1 ]
Incorvaia, Carlo [1 ]
Perri, Paolo [1 ]
D'Angelo, Sergio [1 ]
Lamberti, Giuseppe [1 ]
Sebastiani, Adolfo [1 ]
机构：
[1] Univ Ferrara, Dept Ophthalmol, I-44100 Ferrara, Italy
来源：
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY | 2007年 / 63卷 / 03期
关键词：
dorzolamide; intraocular pressure; juvenile primary open-angle glaucoma; retinal blood flow; timolol;
D O I：
10.1111/j.1365-2125.2006.02768.x
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Aim To investigate whether dorzolamide modifies peripapillary retinal haemodynamics in juvenile primary open-angle glaucoma (JPOAG) patients treated with timolol. Methods In 40 JPOAG subjects, before and after dorzolamide coadministration with timolol, the following examinations were achieved: intraocular pressure (IOP), blood pressure (BP), ocular perfusion pressure (OPP), heart rate (HR), visual field and retinal flowmetry. Results Adjunctive therapy with dorzolamide induced the following modifications: IOP reduction [1.75 mmHg, 95% confidence interval (CI) 1.23, 2.26; P < 0.05], OPP increase (5.09 mmHg, 95% CI 2.97, 7.20; P < 0.02) and retinal blood flow improvement (35.0 arbitrary units, 95% CI 12.20, 57.80; P < 0.03). BP, HR and visual field indices did not change. Conclusions Dorzolamide, in association or in fixed combination with timolol, significantly improves retinal blood flow in JPOAG patients.
引用
收藏
页码：376 / 379
页数：4
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