Immunotherapy with regulatory T cells in transplantation

被引：9
|
作者：
Peters, J. H. [1 ]
Koenen, H. J. P. M. [1 ]
Hilbrands, L. B. [2 ]
Joosten, I. [1 ]
机构：
[1] Radboud Univ Nijmegen, Med Ctr, Dept Blood Transfus & Transplantat Immunol, NL-6500 HB Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Med Ctr, Dept Nephrol, NL-6500 HB Nijmegen, Netherlands
来源：
IMMUNOTHERAPY | 2009年 / 1卷 / 05期
关键词：
immunosuppression; immunotherapy; regulatory T cell; tolerance; transplantation; VERSUS-HOST-DISEASE; HUMAN DENDRITIC CELLS; IN-VITRO EXPANSION; MEDIATED SUPPRESSION; ALLOGRAFT-REJECTION; PERIPHERAL-BLOOD; FOXP3; EXPRESSION; CYCLOSPORINE-A; CUTTING EDGE; TGF-BETA;
D O I：
10.2217/IMT.09.45
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Regulatory T cell (Treg)-based immunotherapy is of great interest to induce tolerance in clinical transplantation settings. In fact, the first clinical trials of Treg infusion after stem cell transplantation have recently begun. However, many important issues regarding human Treg immunotherapy are still to be resolved. In this review, we provide a short update on Tregs and elaborate on various strategies for Treg-based immunotherapy. First, infusion of ex vivo-selected naturally occurring Tregs is addressed, with emphasis on Treg isolation, expansion, antigen specificity, homing and stability. Next, the potential of ex vivo-induced Treg transfusion strategies is discussed. Finally, therapies aimed at in vivo increase of Treg numbers or function are addressed. In addition, we summarize the current knowledge on effects of immunosuppressive drugs on Tregs. In the following years, we expect exciting new data regarding the clinical application of Treg immunotherapy in transplantation to be released.
引用
收藏
页码：855 / 871
页数：17
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