Pigment Epithelium-Derived Factor, a Protective Factor for Photoreceptors in Vivo

被引：37
|
作者：
Polato, Federica [1 ]
Becerra, S. Patricia [1 ]
机构：
[1] NEI, Sect Prot Struct & Funct, Lab Retinal Cell & Mol Biol, NIH, NIH NEI BG 6,Room 134,6 Ctr Dr MSC 0608, Bethesda, MD 20892 USA
来源：
RETINAL DEGENERATIVE DISEASES: MECHANISMS AND EXPERIMENTAL THERAPY | 2016年 / 854卷
关键词：
PEDF; Retinal degeneration; Neuroprotection; Photoreceptor; Animal models; INDUCED CELL-DEATH; RETINAL DEGENERATION; ROYAL-COLLEGE; SURGEONS RATS; GENE-TRANSFER; FACTOR PEDF; RCS RAT; RECEPTOR; IDENTIFICATION; MECHANISMS;
D O I：
10.1007/978-3-319-17121-0_93
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Pigment epithelium-derived factor (PEDF) is a natural protein of the retina with demonstrable neurotrophic properties, found in the interphotoreceptor matrix in intimate contact with photoreceptors. This review summarizes the effects of PEDF on photoreceptors in several animal models of retinal degeneration.
引用
收藏
页码：699 / 706
页数：8
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