Triterpenoid saponins with anti-inflammatory activities from Ilex pubescens roots

被引：38

作者：

Wu, Peng ^{[1
]}

Gao, Hui ^{[1
]}

Liu, Jian-Xin ^{[2
]}

Liu, Liang ^{[2
]}

Zhou, Hua ^{[2
]}

Liu, Zhong-Qiu ^{[1
,2
]}

机构：

[1] Guangzhou Univ Chinese Med, Int Inst Translat Chinese Med, Guangzhou 510006, Guangdong, Peoples R China

[2] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Taipa, Macau, Peoples R China

来源：

PHYTOCHEMISTRY | 2017年 / 134卷

基金：

中国国家自然科学基金;

关键词：

Ilex pubescens; Aquifoliaceae; Triterpenoid saponins; RAW; 264.7; macrophages; Anti-inflammatory; SELECTIVE INHIBITORS; LEAVES; INFLAMMATION; DERIVATIVES; MECHANISMS; GLYCOSIDES; OBLONGA;

D O I：

10.1016/j.phytochem.2016.11.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Seven triterpenoid saponins, named ilexsaponin I-O, along with twelve known ones, were isolated from the roots of Ilex pubescens. The structures of all compounds were elucidated by use of extensive spectroscopic methods (IR, HR-ESI-MS, and 1D and 2D NMR). Sugar residues obtained after acid hydrolysis were identified by TLC and HPLC. The in vitro anti-inflammatory effects of the triterpenoid saponins were also evaluated in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. Among the isolated saponins, seven compounds were shown to inhibit LPS-induced nitric oxide (NO) and prostaglandin E2 (PGE2) production by suppressing the expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX -2), respectively, in LPS-stimulated RAW 264.7 cells. Ilexsaponin I and beta-D-glucopyranosyl 3-beta-[beta-D-oxylopyranosyl-(1 -> 2)-beta-D-glucopyranosyloxy]-olea-12-en-28-oate exerted more potent antiinflammatory effects than the other compounds tested. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：122 / 132

页数：11

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