A retrospective on the requirements for γδ T-cell development

被引:12
|
作者
Hayes, Sandra M.
Love, Paul E.
机构
[1] NICHHD, Lab Mammalian Genes & Dev, NIH, Bethesda, MD 20892 USA
[2] SUNY Upstate Med Univ, Dept Microbiol & Immunol, Syracuse, NY USA
关键词
gamma delta T cells; T-cell development; alpha beta versus gamma delta T-cell development; developmental; signaling pathways;
D O I
10.1111/j.1600-065X.2006.00476.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Since the discovery of gamma delta T cells two decades ago, considerable effort has been made to understand their developmental program, their antigen specificity, and their contribution to the immune response. In this review, we focus on what is known about gamma delta T-cell development and on the advances that have been made in determining which genes are required. In addition, we compare the genetic requirements for alpha beta and gamma delta T-cell development with the hope of gaining a better picture of the signaling pathways that govern the development of gamma delta lineage cells.
引用
收藏
页码:8 / 14
页数:7
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