Hydroperoxy-cycloartane triterpenoids from the leaves of Markhamia lutea, a plant ingested by wild chimpanzees

被引：26

作者：

Lacroix, Damien ^{[1
]}

Prado, Soizic ^{[1
]}

Deville, Alexandre ^{[1
]}

Krief, Sabrina

Dumontet, Vincent ^{[2
]}

Kasenene, John ^{[3
]}

Mouray, Elisabeth ^{[1
]}

Bories, Christian ^{[4
]}

Bodo, Bernard ^{[1
]}

机构：

[1] Museum Natl Hist Nat, CNRS, Unite Associee, F-75005 Paris, France

[2] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

[3] Makerere Univ, Dept Bot, Kampala, Uganda

[4] Univ Paris 11, CNRS, Fac Pharm, F-92200 Chatenay Malabry, France

来源：

PHYTOCHEMISTRY | 2009年 / 70卷 / 10期

关键词：

Cycloartane; Triterpenoid hydroperoxides; Markhamia lutea; Bignoniaceae; Anti-parasitic activities; Zoopharmacognosy; Chimpanzees; IN-VITRO; UGANDA; GLYCOSIDES; PRIMATES;

D O I：

10.1016/j.phytochem.2009.06.020

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In the framework of the phytochemical investigation of plant species eaten by wild chimpanzees in their natural environment in Uganda, leaf samples of Markhamia lutea were selected and collected. The crude ethyl acetate extract of M. lutea leaves exhibited significant in vitro anti-parasitic activity and low cytotoxicity against MRC5 and KB cells. Fractionation of this extract led to six cycloartane triterpenoids, musambins A-C and their 3-O-xyloside derivatives musambiosides A-C. The structures were elucidated on the basis of spectral studies including mass spectroscopy and extensive 2D NMR. Most of the compounds exhibited mild anti-leishmanial and anti-trypanosomal activities. (C) 2009 Elsevier Ltd. All rights reserved.

引用

页码：1239 / 1245

页数：7

共 29 条

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