Curcumin Induces Autophagic Survival of DCLK1+VE Colon Cancer Stem Cells (CSCs), While Co-Treatment With Curcumin and DCLK1-siRNA Eliminates CSCS: Role of Long and Short Isofoms of DCLK1

被引：0
|
作者：
O'Connell, Malaney R.
Sarkar, Shubhashish
Kantara, Carla
Singh, Pomila
机构：
来源：
GASTROENTEROLOGY | 2014年 / 146卷 / 05期
关键词：
D O I：
暂无
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Sa1959
引用
收藏
页码：S340 / S340
页数：1
相关论文
共 11 条
  • [1] A sub-set of DCLK1+ve colon cancer stem cells (CSCs) survive curcumin induced autophagy, while co-treatment with curcumin+DCLK1-siRNA eliminates CSCs: Role of long and short isofoms of DCLK1
    Sarkar, Shubhashish
    O'Connell, Malaney
    Kantara, Carla
    Singh, Pomila
    CANCER RESEARCH, 2014, 74 (19)
  • [2] Curcumin Promotes Autophagic Survival of a Subset of Colon Cancer Stem Cells, Which Are Ablated by DCLK1-siRNA
    Kantara, Carla
    O'Connell, Malaney
    Sarkar, Shubhashish
    Moya, Stephanie
    Ullrich, Robert
    Singh, Pomila
    CANCER RESEARCH, 2014, 74 (09) : 2487 - 2498
  • [3] Specific human cholangiocarcinoma (CCA) subpopulations of cancer stem cells (CSCs) express DoubleCortin-Like Kinase 1 (DCLK1) and DCLK1 inhibition induces anti-cancer effects
    Nevi, L.
    Di Matteo, S.
    Carpino, G.
    Cardinale, V.
    Zizzari, I.
    Ambrosino, V.
    Costantini, D.
    Safarikia, S.
    Manzi, E.
    Derose, A. M.
    Melandro, F.
    Bragazzi, M. C.
    Grazi, G.
    Berloco, P. B.
    Giuliante, F.
    Gaudio, E.
    Alvaro, D.
    DIGESTIVE AND LIVER DISEASE, 2018, 50 (01) : 5 - 6
  • [4] Dietary chemopreventive agent (curcumin), hypomethylates 5′ promoter of DCLK1 gene in human colon cancer cells and restores expression of long isoform of DCLK1
    Sarkar, Shubhashish
    O'Connell, Malaney
    Singh, Pomila
    CANCER RESEARCH, 2015, 75
  • [5] Differential, dose-dependent, effects of curcumin/analogs, on long (L) versus short (S) isoforms of a cancer stem cell marker, DCLK1, in colon and pancreatic cancer cells: biological impact
    Sarkar, Shubhashish
    Connell, Malaney O.
    Singh, Pomila
    CANCER RESEARCH, 2016, 76
  • [6] Short (S) Isoform of Cancer-Stem-Cell Marker, DCLK1, Is Critically Required for Maintaining Proliferative/Tumorigenic Potential of Human Colon Cancer Cells (hCCCs) Independent of DCLK1-L Isoform
    O'Connell, Malaney R.
    Sarkar, Shubhashish
    Ward, Denise
    Singh, Pomila
    GASTROENTEROLOGY, 2016, 150 (04) : S605 - S605
  • [7] DOUBLECORTIN-LIKE KINASE 1 (DCLK1) IS A MARKER OF SPECIFIC SUBPOPULATIONS OF CANCER STEM CELLS (CSCS) IN HUMAN CHOLANGIOCARCINOMA (CCA) AND ITS INHIBITION EXERTS ANTI-CANCER EFFECTS
    Nevi, L.
    Di Matteo, S.
    Carpino, G.
    Cardinale, V.
    Ambrosino, V.
    Costantini, D.
    Safarikia, S.
    Manzi, E.
    De Rosa, A. M.
    Melandro, F.
    Bragazzi, M. C.
    Grazi, G.
    Berloco, P. B.
    Giuliante, F.
    Gaudio, E.
    Alvaro, D.
    DIGESTIVE AND LIVER DISEASE, 2018, 50 (02) : E86 - E87
  • [8] Curcumin and its Bioavailable Analog (EF24), Differentially Regulate Expression of Long (L) Versus Short (S) Isoforms of DCLK1 in Human Cancer (Colon/Pancreatic) Cells, Dose-Dependently, In Vitro and In Vivo
    Sarkar, Shubhashish
    O'Connell, Malaney R.
    Singh, Pomila
    GASTROENTEROLOGY, 2016, 150 (04) : S623 - S624
  • [9] Short (S) isoform of cancer-stem-cell marker, DCLK1, is critically required to maintain proliferative/tumorigenic potential of colon cancer cells: identification of associated molecular pathways
    O'Connell, Malaney R.
    Sarkar, Shubhashish
    Singh, Pomila
    CANCER RESEARCH, 2014, 74 (19)
  • [10] Opposite Effects of Curcumin on the Expression of Short (S) Form of Stem-Cell-Marker, DCLK1, in Non-Transformed vs Transformed Cells, Resulting in Either Stabilization or Inhibition of Cell Proliferation, Respectively
    Sarkar, Shubhashish
    O'Connell, Malaney R.
    Moya, Stephanie
    Singh, Pomila
    GASTROENTEROLOGY, 2013, 144 (05) : S596 - S596
12