DOUBLECORTIN-LIKE KINASE 1 (DCLK1) IS A MARKER OF SPECIFIC SUBPOPULATIONS OF CANCER STEM CELLS (CSCS) IN HUMAN CHOLANGIOCARCINOMA (CCA) AND ITS INHIBITION EXERTS ANTI-CANCER EFFECTS

被引：0
|
作者：
Nevi, L. [1 ]
Di Matteo, S. [1 ]
Carpino, G. [2 ]
Cardinale, V. [1 ]
Ambrosino, V. [1 ]
Costantini, D. [1 ]
Safarikia, S. [1 ]
Manzi, E. [3 ]
De Rosa, A. M. [4 ]
Melandro, F. [1 ]
Bragazzi, M. C. [1 ]
Grazi, G. [3 ]
Berloco, P. B. [1 ]
Giuliante, F. [3 ]
Gaudio, E. [1 ]
Alvaro, D. [1 ]
机构：
[1] Sapienza Univ Rome, Rome, Italy
[2] Univ Rome Foro Italico, Rome, Italy
[3] Regina Elena Inst Canc Res, Rome, Italy
[4] Univ Cattolica Sacro Cuore, Sch Med, Rome, Italy
来源：
DIGESTIVE AND LIVER DISEASE | 2018年 / 50卷 / 02期
关键词：
D O I：
10.1016/S1590-8658(18)30309-8
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
OC.08.1
引用
收藏
页码：E86 / E87
页数：2
相关论文
共 36 条
  • [1] Specific human cholangiocarcinoma (CCA) subpopulations of cancer stem cells (CSCs) express DoubleCortin-Like Kinase 1 (DCLK1) and DCLK1 inhibition induces anti-cancer effects
    Nevi, L.
    Di Matteo, S.
    Carpino, G.
    Cardinale, V.
    Zizzari, I.
    Ambrosino, V.
    Costantini, D.
    Safarikia, S.
    Manzi, E.
    Derose, A. M.
    Melandro, F.
    Bragazzi, M. C.
    Grazi, G.
    Berloco, P. B.
    Giuliante, F.
    Gaudio, E.
    Alvaro, D.
    DIGESTIVE AND LIVER DISEASE, 2018, 50 (01) : 5 - 6
  • [2] DoubleCortin/Like Kinase 1 (DCLK1) expression characterized specific cancer stem cell subpopulations of human cholangiocarcinoma primary cell cultures where its inhibition exerts anti-neoplastic effects
    Di Matteo, Sabina
    Nevi, Lorenzo
    Cardinale, Vincenzo
    Zizzari, Ilaria Grazia
    Ambrosino, Valeria
    Biancaniello, Francesca
    Costantini, Daniele
    Safarikia, Samira
    De Peppo, Valerio
    De Rose, Agostino Maria
    Melandro, Fabio
    Bragazzi, Mariaconsiglia
    Giuliante, Felice
    Berloco, Pasquale B.
    Grazzi, Gianluca
    Carpino, Guido
    Gaudio, Eugenio
    Alvaro, Domenico
    JOURNAL OF HEPATOLOGY, 2019, 70 (01) : E360 - E361
  • [3] Targeting Doublecortin-like Kinase 1 (DCLK1) in Colon Cancer: An <it>In</it>-<it>silico</it> Approach
    Parsai, Janhvi
    Crockett, Cooper
    Kimball, Hunter
    Raval, Nipam
    FASEB JOURNAL, 2020, 34
  • [4] Expression of a Novel Stem Cell Marker Doublecortin-Like Kinase 1 (DCLK1) in Human Colorectal Polyps and Adenocarcinomas
    Shakir, Faiz
    May, Randal
    Sureban, Sripathi M.
    Lightfoot, Stanley
    Madhoun, Mohammad F.
    Houchen, Courtney W.
    GASTROENTEROLOGY, 2013, 144 (05) : S876 - S877
  • [5] Enhanced Expression of Doublecortin-Like Kinase 1 (DCLK1) in the Background Mucosa of Colon Cancer
    Hirata, Yuki
    Sezaki, Takuhito
    Hagiwara, Teruki
    Edogawa, Shoko
    Okada, Toshihiko
    Inoue, Takuya
    Yano, Hideaki
    Gohda, Yoshimasa
    Suda, Ryuichiro
    Hirose, Yoshinobu
    Kawamura, Yutaka J.
    Higuchi, Kazuhide
    Dohi, Taeko
    Kawamura, Yuki I.
    GASTROENTEROLOGY, 2015, 148 (04) : S572 - S572
  • [6] A putative stem cell marker, doublecortin-like kinase (DCLK1), is involved in the development of hepatocellular carcinoma
    Ali, Naushad
    CANCER RESEARCH, 2013, 73 (08)
  • [7] ROLE OF DOUBLECORTIN-LIKE KINASE 1 (DCLK1) POSITIVE TUFT CELLS IN COLITIS-ASSOCIATED COLORECTAL CANCER
    Shin, Alice E.
    Fazio, Elena N.
    Zhang, Liyue
    Good, Hayley
    Sherman, Philip M.
    Wang, Timothy C.
    Asfaha, Samuel
    GASTROENTEROLOGY, 2018, 154 (06) : S23 - S23
  • [8] First-in-class Doublecortin-like kinase 1 (DCLK1) inhibitor for targeting cancer stem cell in hepatocellular carcinoma.
    Yoon, Daseul
    Jung, Seung Hee
    Jang, Ju Young
    Ahn, Ji-Young
    Jo, Seung Jin
    Ko, Donghyun
    Kim, Dong-kyu
    Yu, Su Jong
    CANCER RESEARCH, 2022, 82 (12)
  • [9] The tumor stem cell marker doublecortin-like kinase (DCLK1) activates inflammatory and carcinogenic signals in hepatocellular carcinoma
    Ali, Naushad
    Chandrakesan, Parthasarathy
    Nguyen, Charles B.
    Husain, Sanam
    Gillaspy, Allison F.
    Huycke, Mark
    Berry, William L.
    May, Randal
    Qu, Dongfeng
    Weygant, Nathaniel
    Sureban, Sripathi M.
    Dhanasekaran, Danny N.
    Houchen, Courtney W.
    CANCER RESEARCH, 2015, 75
  • [10] Doublecortin-like kinase 1 (DCLK1) correlates with Notch pathway signaling, controls metastatic characteristics in head and neck cancer
    Broner, Esther Channah
    Subbannayya, Tejaswini
    Advani, Jayshree
    Zhavoronkov, Alex
    Artemov, Artem
    Ozerov, Ivan
    Sloma, Ido
    Gowda, Harsha
    Sidransky, David
    Izumchenko, Eugene
    Chatterjee, Aditi
    CANCER RESEARCH, 2018, 78 (13)
1234