AN EFFICIENT AND NOVEL PROCESS FOR THE SYNTHESIS OF NIZATIDINE

被引：0

作者：

Srinivasarao, Talasila ^{[1
]}

Mohanty, Sandeep ^{[1
]}

Suryanarayana, Venkata Ch ^{[1
]}

Reddy, G. Sandeep ^{[1
]}

Jaydeepkumar ^{[2
]}

Rao, B. Venkateswara ^{[3
]}

机构：

[1] Dr Reddys Labs Ltd, Proc Res & Dev, API Plant, Plot Nos 116,126C,Survey 157, Ida Bollaram 502325, Telangana, India

[2] Dr Reddys Labs Ltd, Ctr Excellence Integrated Prod Dev, Innovat Plaza, Qutubullapur 500072, Andhra Pradesh, India

[3] Andhra Univ, Dept Engn Chem, Visakhapatnam 500003, Andhra Pradesh, India

来源：

HETEROCYCLIC LETTERS | 2019年 / 9卷 / 02期

关键词：

Ethyl bromopyruvate; 2-(dimethylamino) ethanethioamide; K2CO3; Cysteamine hydrochloride; NaBH4 andN-methyl-1-(methylthio)-2-nitroethenamine; THIAZOLES;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A facile echo friendly, cost effective and robust process for the synthesis of Nizatidine via the cyclocondensation of 2-(dimethylamino) ethanethioamide with ethyl bromopyruvate followed by reduction then coupled with cysteamine hydrochloride. The later formed product was coupled with (N-methyl-1-(methylthio)-2-nitroethenamine in water resulted Nizatidine. The synthesized product was meet European pharmacopeia (EP) monograph.

引用

页码：191 / 195

页数：5

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