CLINICAL TRIAL ENDPOINTS FOR OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN NEOVASCULAR AGE-RELATED MACULAR DEGENERATION

被引：32
|
作者：
Cole, Emily D. [1 ,2 ,3 ]
Ferrara, Daniela [1 ]
Novais, Eduardo A. [1 ,4 ]
Louzada, Ricardo N. [1 ,5 ]
Waheed, Nadia K. [1 ]
机构：
[1] Tufts Med Ctr, New England Eye Ctr, 260 Tremont St,Biewend Bldg,9-11th Floor, Boston, MA 02116 USA
[2] MIT, Dept Elect Engn & Comp Sci, Cambridge, MA 02139 USA
[3] MIT, Elect Res Lab, Cambridge, MA 02139 USA
[4] Univ Fed Goias, Goiania, Go, Brazil
[5] Univ Fed Sao Paulo, Sch Med, Sao Paulo, Brazil
来源：
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 2016年 / 36卷 / 12期
关键词：
optical coherence tomography; optical coherence tomography angiography; neovascular age-related macular degeneration; ENDOTHELIAL GROWTH-FACTOR; CHOROIDAL NEOVASCULARIZATION; ULTRAHIGH-SPEED; OCT ANGIOGRAPHY; TYPE-2; NEOVASCULARIZATION; QUANTITATIVE-ANALYSIS; IMAGE ARTIFACTS; DOSING REGIMEN; RANIBIZUMAB; THERAPY;
D O I：
10.1097/IAE.0000000000001338
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Purpose: To describe qualitative and quantitative optical coherence tomography (OCT) angiography (OCTA) parameters for choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) and their applicability as potential clinical trial endpoints. Methods: A review of current literature related to the topic of OCTA and AMD. Results: There are a number of promising OCTA parameters that can be used to diagnose the presence of CNV and to monitor the activity and progression of the lesion, pre- and post-treatment morphological characteristics, CNV dimensions, and automated quantitative parameters such as vessel density. Conclusion: The OCTA parameters described in this review have promise for the future development of clinical trial endpoints, but require further validation before they can be widely used.
引用
收藏
页码：S83 / S92
页数：10
相关论文
共 50 条
  • [41] Optical Coherence Tomography Biomarkers for Conversion to Exudative Neovascular Age-related Macular Degeneration
    Wakatsuki, Y. U.
    Hirabayashi, Kazutaka
    Yu, Hannah j.
    Marion, Kenneth m.
    Corradetti, Giulia
    Wykoff, Charles c.
    Sadda, Srinivas r.
    AMERICAN JOURNAL OF OPHTHALMOLOGY, 2023, 247 : 137 - 144
  • [42] Optical Coherence Tomography and the Development of Antiangiogenic Therapies in Neovascular Age-Related Macular Degeneration
    Rosenfeld, Philip J.
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2016, 57 (09) : OCT14 - OCT26
  • [43] Comparison of Optical Coherence Tomography Angiography and Indocyanine Green Angiography in Type 1 and 2 Neovascular Age-related Macular Degeneration
    Told, Reinhard
    Sacu, Stefan
    Hecht, Alexander
    Baratsits, Magdalena
    Eibenberger, Katharina
    Kroh, Maria Elisabeth
    Rezar, Sandra
    Schlanitz, Ferdinand Georg
    Pollreisz, Andreas
    Schmidt-Erfurth, Ursula
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2017, 58 (08)
  • [44] Optical Coherence Tomography Angiography for Detecting Nonexudative Macular Neovascularization in Age-Related Macular Degeneration
    Greenberg, Jeremy R.
    Kim, Brian Y.
    Brady, Christopher J.
    Millay, Robert H.
    Raut, Robert
    JOURNAL OF VITREORETINAL DISEASES, 2023, 7 (01) : 16 - 19
  • [45] OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY REVEALS BLOOD FLOW IN CHOROIDAL NEOVASCULAR MEMBRANE IN REMISSION PHASE OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION
    Ichiyama, Yusuke
    Sawada, Tomoko
    Ito, Yuka
    Kakinoki, Masashi
    Ohji, Masahito
    RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES, 2017, 37 (04): : 724 - 730
  • [46] Combined quantitative and qualitative optical coherence tomography angiography biomarkers for predicting active neovascular age-related macular degeneration
    Cherng-Ru Hsu
    Tso-Ting Lai
    Yi-Ting Hsieh
    Tzyy-Chang Ho
    Chung-May Yang
    Chang-Hao Yang
    Scientific Reports, 11
  • [47] Combined quantitative and qualitative optical coherence tomography angiography biomarkers for predicting active neovascular age-related macular degeneration
    Hsu, Cherng-Ru
    Lai, Tso-Ting
    Hsieh, Yi-Ting
    Ho, Tzyy-Chang
    Yang, Chung-May
    Yang, Chang-Hao
    SCIENTIFIC REPORTS, 2021, 11 (01)
  • [48] Silent Type 1 Choroidal Neovascular Membrane in Age-Related Macular Degeneration Detected by Optical Coherence Tomography Angiography
    Tieu, Brian
    Olsen, Matt
    Burnham, Jordan
    Chen, Ching Jygh
    INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2016, 57 (12)
  • [49] Choroid morphometric analysis in non-neovascular age-related macular degeneration by means of optical coherence tomography angiography
    Cicinelli, Maria Vittoria
    Rabiolo, Alessandro
    Marchese, Alessandro
    de Vitis, Luigi
    Carnevali, Adriano
    Querques, Lea
    Bandello, Francesco
    Querques, Giuseppe
    BRITISH JOURNAL OF OPHTHALMOLOGY, 2017, 101 (09) : 1193 - 1200
  • [50] Comparison of Optical Coherence Angiography Measurements in Patients with Neovascular and Non-Neovascular Age-Related Macular Degeneration
    Demir, Mehmet
    Akpolat, Cetin
    Ucak, Turgay
    Yilmaz, Zeynep
    Ozyurek, Emine Betul Akbas
    MEDICAL BULLETIN OF SISLI ETFAL HOSPITAL, 2022, 56 (01): : 107 - 112
12345