Homodimerization and heterodimerization of SlP/EDG sphingosine-1-phosphate receptors

被引：46
|
作者：
Van Brocklyn, JR
Behbahani, B
Lee, NH
机构：
[1] Ohio State Univ, Dept Pathol, Columbus, OH 43210 USA
[2] Inst Genomic Res, Dept Funct Genomics, Rockville, MD 20850 USA
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS | 2002年 / 1582卷 / 1-3期
关键词：
sphingolipid; lysophospholipid; G protein-coupled receptor; dimerization;
D O I：
10.1016/S1388-1981(02)00141-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Sphingosine-l-phosphate (SIP) binds to and signals through several members of a group of G protein-coupled receptors (GPCRs) known as the S1P/EDG family. Several of these receptors are coexpressed in various cell types and recent reports have shown that biological effects of S1P often require more than one SIP receptor subtype. Recent evidence indicates that many GPCRs exist as dimers. We show that SIP receptors form both homodimers as well as heterodimers with other members of the S1P subfamily of receptors. We also discuss the role that GPCR dimers play in receptor function and what this may mean for SIP signaling. (C) 2002 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：89 / 93
页数：5
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