High-level fluoroquinolone resistance in a clinical Streptoccoccus pyogenes isolate in Germany

被引：27
|
作者：
Reinert, RR [1 ]
Lütticken, R [1 ]
Al-Lahham, A [1 ]
机构：
[1] Univ Hosp, Natl Reference Ctr Streptococci, Inst Med Microbiol, D-52057 Aachen, Germany
来源：
CLINICAL MICROBIOLOGY AND INFECTION | 2004年 / 10卷 / 07期
关键词：
Emm typing; fluoroquinolone resistance; multilocus sequence typing; resistance; Streptococcus pyogenes;
D O I：
10.1111/j.1469-0691.2004.00890.x
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
An isolate of Streptococcus pyogenes isolated from a 63-year-old woman with a serious wound infection was found to be highly resistant to fluoroquinolones (levofloxacin MIC greater than or equal to 32 mg/L). DNA amplification and sequencing revealed a serine-81 to phenylalanine substitution in gyrA and three substitutions in parC: serine-79 to phenylalanine, aspartic acid-91 to asparagine, and serine-140 to proline. To our knowledge, this is the first report from a European country of a clinical isolate of S. pyogenes with high-level fluoroquinolone resistance.
引用
收藏
页码：659 / 662
页数：5
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