The regulation of protein translation and its implications for cancer

被引：74

作者：

Song, Ping ^{[1
]}

Yang, Fan ^{[2
]}

Jin, Hongchuan ^{[3
]}

Wang, Xian ^{[1
]}

机构：

[1] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Canc Inst,Dept Med Oncol, Hangzhou, Zhejiang, Peoples R China

[2] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Hepatobiliary & Pancreat Surg, Hangzhou, Zhejiang, Peoples R China

[3] Zhejiang Univ, Sir Run Run Shaw Hosp, Sch Med, Key Lab Biotherapy Zhejiang, Hangzhou, Zhejiang, Peoples R China

来源：

SIGNAL TRANSDUCTION AND TARGETED THERAPY | 2021年 / 6卷 / 01期

基金：

中国国家自然科学基金;

关键词：

MESSENGER-RNA TRANSLATION; CELL-PROLIFERATION; GENE-EXPRESSION; DEPENDENT TRANSLATION; COLORECTAL-CANCER; ESCHERICHIA-COLI; CODON OPTIMALITY; P53; TRANSLATION; NONCODING RNAS; GROWTH-FACTOR;

D O I：

10.1038/s41392-020-00444-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In addition to the deregulation of gene transcriptions and post-translational protein modifications, the aberrant translation from mRNAs to proteins plays an important role in the pathogenesis of various cancers. Targeting mRNA translation are expected to become potential approaches for anticancer treatments. Protein translation is affected by many factors including translation initiation factors and RNA-binding proteins. Recently, modifications of mRNAs mainly N6-methyladenine (m(6)A) modification and noncoding RNAs, such as microRNAs and long noncoding RNAs are involved. In this review, we generally summarized the recent advances on the regulation of protein translation by the interplay between mRNA modifications and ncRNAs. By doing so, we hope this review could offer some hints for the development of novel approaches in precision therapy of human cancers.

引用

页数：9

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