miR-143 Inhibits NSCLC Cell Growth and Metastasis by Targeting Limk1

被引：49

作者：

Xia, Hui ^{[1
]}

Sun, Shengjie ^{[2
]}

Wang, Bo ^{[3
]}

Wang, Tao ^{[3
]}

Liang, Chaoyang ^{[3
]}

Li, Guo ^{[3
]}

Huang, Chongbiao ^{[4
]}

Qi, Daliang ^{[4
]}

Chu, Xiangyang ^{[3
]}

机构：

[1] Peoples Liberat Army Gen Hosp, Affiliated Hosp 1, Dept Thorac Cardio Surg, Beijing 100048, Peoples R China

[2] Gen Hosp Peoples Liberat Army, Dept Med Oncol, Beijing 100853, Peoples R China

[3] Gen Hosp Peoples Liberat Army, Dept Thorac Surg, Beijing 100853, Peoples R China

[4] Tianjin Med Univ, Canc Inst & Hosp, Dept Senior Ward, Key Lab Canc Prevent & Therapy Tianjin, Tianjin 300060, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2014年 / 15卷 / 07期

关键词：

miR-143; NSCLC; Limk1; proliferation; migration; invasion; LUNG-CANCER CELLS; DOWN-REGULATION; MICRORNA-143; PROLIFERATION; EXPRESSION; MIGRATION; DIAGNOSIS; MOTILITY; INVASION;

D O I：

10.3390/ijms150711973

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) have essential roles in carcinogenesis and tumor progression. Here, we investigated the roles and mechanisms of miR-143 in non-small cell lung cancer (NSCLC). miR-143 was significantly decreased in NSCLC tissues and cell lines. Overexpression of miR-143 suppressed NSCLC cell proliferation, induced apoptosis, and inhibited migration and invasion in vitro. Integrated analysis identified LIM domain kinase 1 (Limk1) as a direct and functional target of miR-143. Overexpression of Limk1 attenuated the tumor suppressive effects of miR-143 in NSCLC cells. Moreover, miR-143 was inversely correlated with Limk1 expression in NSCLC tissues. Together, our results highlight the significance of miR-143 and Limk1 in the development and progression of NSCLC.

引用

页码：11973 / 11983

页数：11

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