YC-1, an activation inductor of soluble guanylyl cyclase

被引:3
|
作者
Santos, JSD [1 ]
Collot, V [1 ]
Bureau, I [1 ]
Rault, S [1 ]
机构
[1] Univ Caen, Ctr Etudes & Rech Medicament Normandie, F-14032 Caen, France
关键词
D O I
10.1107/S0108270100007393
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The crystal structure of 1-benzyl-3-(5-hydroxymethyl-2-furyl)indazole, C19H16N2O2, showed that the furan O and indazole N atoms lie on the same face of the molecule. The crystal packing consists of intermolecular hydrogen bonding, and indazole-indazole and indazole-phenyl interactions.
引用
收藏
页码:1035 / 1036
页数:2
相关论文
共 50 条
  • [31] Synthesis and evaluation of a phosphonate analogue of the soluble guanylate cyclase activator YC-1
    Martin, Nathaniel I.
    Derbyshire, Emily R.
    Marletta, Michael A.
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (17) : 4938 - 4941
  • [32] Kinetics and equilibria of soluble guanylate cyclase ligation by CO: Effect of YC-1
    Kharitonov, VG
    Sharma, VS
    Magde, D
    Koesling, D
    BIOCHEMISTRY, 1999, 38 (33) : 10699 - 10706
  • [33] Interaction of soluble guanylate cyclase with YC-1: Kinetic and resonance Raman studies
    Denninger, JW
    Schelvis, JPM
    Brandish, PE
    Zhao, Y
    Babcock, GT
    Marletta, MA
    BIOCHEMISTRY, 2000, 39 (14) : 4191 - 4198
  • [34] The Soluble Guanylyl Cyclase Activator YC-1 Increases Intracellular cGMP and cAMP via Independent Mechanisms in INS-1E Cells
    Ramos-Espiritu, Lavoisier S.
    Hess, Kenneth C.
    Buck, Jochen
    Levin, Lonny R.
    JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2011, 338 (03): : 925 - 931
  • [35] Purified soluble guanylyl cyclase expressed in a baculovirus/Sf9 system:: stimulation by YC-1, nitric oxide, and carbon monoxide
    Hoenicka, M
    Becker, EM
    Apeler, H
    Sirichoke, T
    Schröder, H
    Gerzer, R
    Stasch, JP
    JOURNAL OF MOLECULAR MEDICINE-JMM, 1999, 77 (01): : 14 - 23
  • [36] Purified soluble guanylyl cyclase expressed in a baculovirus/Sf9 system: stimulation by YC-1, nitric oxide, and carbon monoxide
    M. Hoenicka
    Eva-Maria Becker
    Heiner Apeler
    T. Sirichoke
    Henning Schröder
    Rupert Gerzer
    Johannes-Peter Stasch
    Journal of Molecular Medicine, 1999, 77 : 14 - 23
  • [37] Activation of soluble guanylate cyclase causes relaxation of corpus cavernosum tissue: synergism of nitric oxide and YC-1
    M Nakane
    G Hsieh
    L N Miller
    R Chang
    M A Terranova
    R B Moreland
    T Kolasa
    J D Brioni
    International Journal of Impotence Research, 2002, 14 : 121 - 127
  • [38] Binding of YC-1/BAY 41-2272 to soluble guanylate cyclase: A new perspective to the mechanism of activation
    Pal, Biswajit
    Kitagawa, Teizo
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 397 (03) : 375 - 379
  • [39] Activation of soluble guanylate cyclase causes relaxation of corpus cavernosum tissue: synergism of nitric oxide and YC-1
    Nakane, M
    Hsieh, G
    Miller, LN
    Chang, R
    Terranova, MA
    Moreland, RB
    Kolasa, T
    Brioni, JD
    INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH, 2002, 14 (02) : 121 - 127
  • [40] YC-1 induces structural changes in the heme pocket of soluble guanylate cyclase.
    Schelvis, JPM
    Denninger, JR
    Zhao, YD
    Brandish, PE
    Marletta, MA
    Babcock, GT
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1999, 217 : U1126 - U1126