Volumetric monochromatic x-ray tomography of the lungs

被引:1
|
作者
Paschal, CB [1 ]
Carroll, FE [1 ]
Worrell, JA [1 ]
Mendenhall, MH [1 ]
Traeger, R [1 ]
Waters, JW [1 ]
Brzymialkiewicz, CN [1 ]
Banks, GA [1 ]
机构
[1] Vanderbilt Univ, Dept Biomed Engn, Nashville, TN 37235 USA
来源
BIOMEDICAL APPLICATIONS OF FREE-ELECTRON LASERS | 2000年 / 3925卷
关键词
monochromatic; x-ray; imaging; tomography; three-dimensional; pulmonary; lungs;
D O I
10.1117/12.384251
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Monochromatic x-rays were produced by inverse Compton scattering resulting from counter-propagation of a tunable free electron laser electron beam and its own infrared photon beam In a manner analogous to electron beam CT, a mechanism was developed here for obtaining multiple projection views with monochromatic x-rays by deflecting x-rays off of mosaic crystals mounted on rotating stages. These crystals are both energy and angle selective. X-rays are detected digitally when they strike a phosphorescent screen mounted in front of a CCD camera. Using this system, multiple projection images of a three-dimensional (3D) phantom and of rat lungs ex vivo were obtained. In an alternate micro-CT arrangement, rat lungs in situ were imaged by rotating the rat in front of both a polychromatic beam from a molybdenum target x-ray tube and the same beam monochromatized with a mosaic crystal. In the first arrangement, depth information was revealed by relative position changes of features seen in each projection and the similar to 0.16 mm thick walls of a catheter were visible in the images. Using conventional tomography, the projections were reconstructed into slice images. Overall, these monochromatic x-ray imaging methods offer reduced x-ray dose, the potential for improved contrast resolution, and now 3D information.
引用
收藏
页码:2 / 7
页数:6
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