Minimising solvent usage in high speed, high loading, and high resolution isocratic dynamic extraction

被引：56
|
作者：
Garrard, Ian J. [1 ]
Janaway, Lee [1 ]
Fisher, Derek [1 ]
机构：
[1] Brunel Univ, Brunel Inst Bioengn, Uxbridge UB8 3PH, Middx, England
来源：
JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES | 2007年 / 30卷 / 02期
关键词：
countercurrent chromatography; CCC; dynamic extraction; recycling;
D O I：
10.1080/10826070601077252
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The development of the planetary-motion countercurrent chromatography machine into a high speed, high loading and high resolution dynamic extraction centrifuge has allowed the scale-up of the technique from analytical to pilot (kg/day). At this scale, solvent usage is a major consideration for both economical and environmental ("green") reasons. The analysis by gas chromatography of the composition of the two phases in solvent systems allows each layer to be made separately as required, minimising solvent wastage. Furthermore, as operation is generally isocratic, analysis of the recovered condensate from evaporated fractions allows the mobile phase to be easily reconstituted ready for re-use in the centrifuge. Such recycling further minimises solvent usage during preparative and pilot-scale separations.
引用
收藏
页码：151 / 163
页数：13
相关论文
共 50 条
  • [31] METRICATION - USAGE OF HIGH SPEED JOBBERS DRILLS
    DORMER, A
    MACHINERY AND PRODUCTION ENGINEERING, 1970, 117 (3010): : 157 - &
  • [32] A novel high speed, high resolution, ultrasound imaging system
    Lasser, M
    Harrison, G
    ASNT FALL CONFERENCE AND QUALITY TESTING SHOW: PAPER SUMMARIES, 1997, : 196 - 198
  • [33] A novel high speed, high resolution, ultrasound imaging system
    Lasser, M
    COMPPOSITES FOR THE REAL WORLD, 1997, 29 : 179 - 185
  • [34] HIGH-SPEED HIGH-RESOLUTION ULTRASONOGRAPHY.
    Singh, S.
    Tandon, S.N.
    Gupta, H.M.
    Medical and Biological Engineering and Computing, 1987, 25 (05): : 585 - 589
  • [35] High Speed, High Resolution Analysis of Flavanones in Citrus Juice
    Erxleben, Bjoern-Thoralf
    LC GC EUROPE, 2009, : 17 - 17
  • [36] A HIGH-SPEED, HIGH-RESOLUTION REMOTE MCA
    ROBERTS, DJ
    GREGORIO, JJ
    IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 1985, 32 (01) : 100 - 104
  • [37] High-Resolution High-Speed LIBS Microscopy
    Tercier, A.
    Vasileva, E.
    Alvarez-Llamas, C.
    Fabre, C.
    Hermelin, S.
    Soula, B.
    Trichard, F.
    Dujardin, C.
    Motto-Ros, V.
    SPECTROSCOPY, 2023, 38 (11) : 34 - 38
  • [38] High resolution ISAR imaging of high speed moving targets
    Xing, M
    Wu, R
    Bao, Z
    IEE PROCEEDINGS-RADAR SONAR AND NAVIGATION, 2005, 152 (02) : 58 - 67
  • [39] HIGH-SPEED AND HIGH-RESOLUTION COMPARATOR.
    Tiponut, V.
    Electronic Engineering (London), 1979, 51 (624):
  • [40] A time interval measuring technique with high speed and high resolution
    Qiu Duyu
    Guo Lianping
    Tan Feng
    Zeng Hao
    PROCEEDINGS OF 2017 13TH IEEE INTERNATIONAL CONFERENCE ON ELECTRONIC MEASUREMENT & INSTRUMENTS (ICEMI), VOL 1, 2017, : 113 - 119
12345