Expression and production of aberrant PAX5 with deletion of exon 8 in B-lineage acute lymphoblastic leukaemia of children

被引:14
|
作者
Sadakane, Y.
Zaitsu, M.
Nishi, M.
Sugita, K.
Mizutani, S.
Matsuzaki, A.
Sueoka, E.
Hamasaki, Y.
Ishii, E.
机构
[1] Saga Univ, Dept Paediat, Saga 8498501, Japan
[2] Univ Yamanashi, Dept Paediat, Chuo Ku, Yamanashi, Japan
[3] Tokyo Med & Dent Univ, Dept Paediat & Dev Biol, Tokyo, Japan
[4] Kyushu Univ, Sch Hlth Sci, Div Child Hlth, Fukuoka 812, Japan
[5] Saga Univ, Dept Internal Med, Saga 8498501, Japan
关键词
Pax5; acute lymphoblastic leukaemia; children; BLNK;
D O I
10.1111/j.1365-2141.2006.06425.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We investigated PAX5 expression in childhood B-lineage acute lymphoblastic leukaemia (ALL). Seven of 21 children with B-lineage ALL had multiple PAX5 variants, while 14 children and healthy controls showed full-length (FL) and one variant PAX5. By Western blotting, healthy controls displayed Pax5-FL, while one short Pax5, derived from the deletion of exon 8 (Pax5-Delta E8) was produced in 90% of ALL samples, as well as in ALL cell lines. PAX5-Delta E8 lacked more than 50% of the transactivation domain, indicating that aberrant Pax5 production might lead to the arrest of B-cell differentiation, contributing to the pathogenesis of B-lineage ALL.
引用
收藏
页码:297 / 300
页数:4
相关论文
共 50 条
  • [31] Detection of minimal residual disease in B-lineage acute lymphoblastic leukaemia by quantitative flow cytometry
    Farahat, N
    Morilla, A
    Owusu-Ankomah, K
    Morilla, R
    Pinkerton, CR
    Treleaven, JG
    Matutes, E
    Powles, RL
    Catovsky, D
    BRITISH JOURNAL OF HAEMATOLOGY, 1998, 101 (01) : 158 - 164
  • [32] Prognostic Impact of Neuropilin-1 Expression in Egyptian Children with B-lineage Acute Lymphoblastic Leukemia
    Hagag, Adel A.
    Nosair, Nahla A.
    MEDITERRANEAN JOURNAL OF HEMATOLOGY AND INFECTIOUS DISEASES, 2015, 7
  • [33] Prediction of Relapse By microRNA Expression in Pediatric B-Lineage Acute Lymphoblastic Leukemia
    Yaniv, Isaac
    Lebel, Asaf
    Shichrur, Keren
    Kordi, Oshrit
    Ohali, Anat
    Hameiri-Grossman, Michal
    Verly, Iedan R. N.
    Kaspers, Gertjan J. L.
    Cloos, Jacqueline
    Fronkova, Eva
    Trka, Jan
    Luria, Drorit
    Kodman, Yona
    Mirsky, Hadar
    Gaash, Dafna
    Jeison, Marta
    Avrahami, Galia
    Elitzur, Sarah
    Gilad, Gil
    Stark, Batia
    Avigad, Smadar
    BLOOD, 2014, 124 (21)
  • [34] Chemokine receptor expression and function in childhood acute lymphoblastic leukemia of B-lineage
    Corcione, A
    Arduino, N
    Ferretti, E
    Pistorio, A
    Spinelli, M
    Ottonello, L
    Dallegri, F
    Basso, G
    Pistoia, V
    LEUKEMIA RESEARCH, 2006, 30 (04) : 365 - 372
  • [35] Epigenetic regulation of PAX5 expression in acute T-cell lymphoblastic leukemia
    Huetter, Gero
    Kaiser, Martin
    Neumann, Martin
    Mossner, Maximilian
    Nowak, Daniel
    Baldus, Claudia D.
    Goekbuget, Nicola
    Hoelzer, Dieter
    Thiel, Eckhard
    Hofmann, Wolf-Karsten
    LEUKEMIA RESEARCH, 2011, 35 (05) : 614 - 619
  • [36] Comparison Of Clinical Implications Of p16 Deletion In B-Lineage Acute Lymphoblastic Leukemia
    Xu, Na
    Xiao, Xiaozhen
    Zhou, Xuan
    Gao, Guanlun
    Xiao, Yajuan
    Du, Qingfeng
    Liu Xiaoli
    BLOOD, 2013, 122 (21)
  • [37] PAX5 as a new marker for acute leukemias: higher B-lineage specificity than CD79a and selective association with t(8;21)AML.
    Tiacci, E
    Orleth, A
    Diverio, D
    Pileri, S
    Lo Coco, F
    Falini, B
    BLOOD, 2003, 102 (11) : 21A - 22A
  • [38] A fourth case of 8p11 myeloproliferative disorder transforming to B-lineage acute lymphoblastic leukaemia - A case report
    JabbarAl-Obaidi, M
    Rymes, N
    White, P
    Pomfret, M
    Smith, H
    Starczynski, J
    Johnson, R
    ACTA HAEMATOLOGICA, 2002, 107 (02) : 98 - 100
  • [39] Loss of CBL E3-ligase activity in B-lineage childhood acute lymphoblastic leukaemia
    Martinelli, Simone
    Checquolo, Saula
    Consoli, Federica
    Stellacci, Emilia
    Rossi, Cesare
    Silvano, Marianna
    Franciosa, Giulia
    Flex, Elisabetta
    Cossu, Carla
    De Luca, Alessandro
    Foa, Robin
    Cazzaniga, Giovanni
    Biondi, Andrea
    Screpanti, Isabella
    Tartaglia, Marco
    BRITISH JOURNAL OF HAEMATOLOGY, 2012, 159 (01) : 115 - 119
  • [40] High-risk B-cell acute lymphoblastic leukaemia presenting with hypereosinophilia and acquiring a novel PAX5 fusion on relapse
    McClure, Barbara J.
    Heatley, Susan L.
    Rehn, Jacqueline
    Breen, James
    Sutton, Rosemary
    Hughes, Timothy P.
    Suppiah, Ram
    Revesz, Tamas
    Osborn, Michael
    White, Daniel
    Yeung, David T.
    White, Deborah L.
    BRITISH JOURNAL OF HAEMATOLOGY, 2020, 191 (02) : 301 - 304