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Expression and production of aberrant PAX5 with deletion of exon 8 in B-lineage acute lymphoblastic leukaemia of children
被引:14
|作者:
Sadakane, Y.
Zaitsu, M.
Nishi, M.
Sugita, K.
Mizutani, S.
Matsuzaki, A.
Sueoka, E.
Hamasaki, Y.
Ishii, E.
机构:
[1] Saga Univ, Dept Paediat, Saga 8498501, Japan
[2] Univ Yamanashi, Dept Paediat, Chuo Ku, Yamanashi, Japan
[3] Tokyo Med & Dent Univ, Dept Paediat & Dev Biol, Tokyo, Japan
[4] Kyushu Univ, Sch Hlth Sci, Div Child Hlth, Fukuoka 812, Japan
[5] Saga Univ, Dept Internal Med, Saga 8498501, Japan
关键词:
Pax5;
acute lymphoblastic leukaemia;
children;
BLNK;
D O I:
10.1111/j.1365-2141.2006.06425.x
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
We investigated PAX5 expression in childhood B-lineage acute lymphoblastic leukaemia (ALL). Seven of 21 children with B-lineage ALL had multiple PAX5 variants, while 14 children and healthy controls showed full-length (FL) and one variant PAX5. By Western blotting, healthy controls displayed Pax5-FL, while one short Pax5, derived from the deletion of exon 8 (Pax5-Delta E8) was produced in 90% of ALL samples, as well as in ALL cell lines. PAX5-Delta E8 lacked more than 50% of the transactivation domain, indicating that aberrant Pax5 production might lead to the arrest of B-cell differentiation, contributing to the pathogenesis of B-lineage ALL.
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页码:297 / 300
页数:4
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