Development and pre-clinical assessment of a first-in-class small molecule inhibitor of FLIP

被引:2
|
作者
Higgins, Catherine A. [1 ]
Fox, Jennifer [1 ]
Majkut, Joanna [1 ]
Fiedler, Greti E. [1 ]
Roberts, Jamie [1 ]
Humphreys, Luke [1 ]
Boffey, Ray J. [2 ]
Perrior, Trevor R. [2 ]
Harrison, Timothy [1 ]
Longley, Daniel B. [1 ]
机构
[1] Queens Univ Belfast, Belfast, Antrim, North Ireland
[2] Domainex Ltd, Saffron Walden CB10 1XL, Essex, England
基金
英国惠康基金;
关键词
D O I
10.1158/1538-7445.AM2019-382
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
382
引用
收藏
页数:2
相关论文
共 50 条
  • [41] FDA approves first-in-class SYK inhibitor
    Mullard, Asher
    NATURE REVIEWS DRUG DISCOVERY, 2018, 17 (06) : 385 - 385
  • [42] FDA approves first-in-class AKT inhibitor
    Asher Mullard
    Nature Reviews Drug Discovery, 2024, 23 : 9 - 9
  • [43] FDA approves first-in-class SYK inhibitor
    Asher Mullard
    Nature Reviews Drug Discovery, 2018, 17 : 385 - 385
  • [44] Romosozumab: A first-in-class scierostin inhibitor for osteoprosis
    Prather, Caitlin
    Adams, Erin
    Zentgraf, Whitney
    AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY, 2020, 77 (23) : 1949 - 1956
  • [45] Small-Molecule Cftr Modulators In Pre-Clinical Development For The Treatment Of Chronic Obstructive Pulmonary Disease
    Drew, L.
    Miller, J. P.
    Green, O.
    Villella, A.
    Kanmert, D.
    McEwan, B.
    Bastos, C.
    Longo, K.
    Ivarsson, M.
    Munoz, B.
    Lee, P. -S.
    Mehmet, H.
    Haeberlein, M.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2016, 193
  • [46] First-in-Class Small Molecule Degrader of Pregnane X Receptor Enhances Chemotherapy Efficacy
    Huber, Andrew D.
    Jung, Young-Hwan
    Li, Yongtao
    Lin, Wenwei
    Wu, Jing
    Poudel, Shyaron
    Carrigan, Annalise G.
    Mishra, Ashutosh
    High, Anthony A.
    Chen, Taosheng
    JOURNAL OF MEDICINAL CHEMISTRY, 2024, 67 (20) : 18549 - 18575
  • [47] A decade of approved first-in-class small molecule orphan drugs: Achievements, challenges and perspectives
    Gu, Jinying
    Wu, Qiuyu
    Zhang, Qiuyue
    You, Qidong
    Wang, Lei
    EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2022, 243
  • [48] Pexidartinib, a Novel Small Molecule CSF-1R Inhibitor in Use for Tenosynovial Giant Cell Tumor: A Systematic Review of Pre-Clinical and Clinical Development
    Benner, Brooke
    Good, Logan
    Quiroga, Dionisia
    Schultz, Thomas E.
    Kassem, Mahmoud
    Carson, William E.
    Cherian, Mathew A.
    Sardesai, Sagar
    Wesolowski, Robert
    DRUG DESIGN DEVELOPMENT AND THERAPY, 2020, 14 : 1693 - 1704
  • [49] Synergistic effects of RPT1G, a first-in-class small molecule NAMPT inhibitor, with venetoclax and olaparib in hematological malignancies
    Crimmins, Gregory
    Wu, Min
    Roushar, Francis
    Bhurruth-Alcor, Yushma
    Jarvela, Timothy
    Digel, James
    Robb, Caroline
    Moghaddam-Taaheri, Parisa
    De Jesus-Diaz, Dennise
    McCormick, Frank
    JOURNAL OF CLINICAL ONCOLOGY, 2024, 42 (16)
  • [50] Development of Bevirimat (PA-457): first-in-class HIV maturation inhibitor
    Graham P Allaway
    Retrovirology, 3