Ionic liquid modified N-doped graphene as a potential platform for the electrochemical discrimination of DNA sequences

被引：22
|
作者：
Sukumaran, Preethi [1 ]
Vineesh, Thazhe Veettil [1 ]
Rajappa, Sivamathini [1 ]
Li, Chen-Zhong [2 ]
Alwarappan, Subbiah [1 ]
机构：
[1] CSIR, Cent Elect Res Inst, Electrod & Electrocatalysis Div, Karaikkudi 630003, Tamil Nadu, India
[2] Florida Int Univ, Nanobiosensors Bioelect Lab, Miami, FL 33174 USA
来源：
SENSORS AND ACTUATORS B-CHEMICAL | 2017年 / 247卷
关键词：
N-doped graphene; Ionic liquid; Label free platform; DNA mutation; SINGLE-LAYER GRAPHENE; SENSOR; ADSORPTION; ELECTRODE; GRAPHITE; OXIDE;
D O I：
10.1016/j.snb.2017.03.078
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Inventive designs for DNA-based electrochemical sensing are emerging tremendously in recent years. Herein, we report a label free ionic liquid (1-butyl-3-methylimidazolinium tetrafluoroborate) modified nitrogen doped graphene electrode as a potential platform for the electrochemical discrimination of complementary and non-complementary DNA sequences. The proposed platform holds a great promise for the rapid and selective hand-held detection of DNA sequences with a sensitivity and detection limit of 0.202 mu A/nM/mm(2) and 8.12 nM respectively, without any expensive labeling and cross-hybridization artifacts. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：556 / 563
页数：8
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