Differentiate Horizontal Pleiotropy from Mediation Using GWAS Summary Statistics in Combining Mendelian Randomization Analysis

被引:0
|
作者
Li, Xiaoyin [1 ]
Ni, Xumin [1 ]
Zhu, Xiaofeng [1 ]
机构
[1] Case Western Reserve Univ, Sch Med, Dept Populat & Quantitat Hlth Sci, Cleveland, OH USA
关键词
D O I
暂无
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
143
引用
收藏
页码:925 / 925
页数:1
相关论文
共 50 条
  • [21] Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
    Marie Verbanck
    Chia-Yen Chen
    Benjamin Neale
    Ron Do
    Nature Genetics, 2018, 50 : 693 - 698
  • [22] Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
    Verbanck, M.
    Chen, C.
    Neale, B.
    Ron, D.
    EUROPEAN JOURNAL OF HUMAN GENETICS, 2019, 27 : 854 - 855
  • [23] Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases
    Verbanck, Marie
    Chen, Chia-Yen
    Neale, Benjamin
    Do, Ron
    NATURE GENETICS, 2018, 50 (05) : 693 - +
  • [24] TEMR: Trans-ethnic mendelian randomization method using large-scale GWAS summary datasets
    Hou, Lei
    Wu, Sijia
    Yuan, Zhongshang
    Xue, Fuzhong
    Li, Hongkai
    Hou, Lei
    Wu, Sijia
    Yuan, Zhongshang
    Xue, Fuzhong
    Li, Hongkai
    AMERICAN JOURNAL OF HUMAN GENETICS, 2025, 112 (01)
  • [25] Inference of Causal Networks Using Bi-directional Mendelian Randomization and Network Deconvolution with GWAS Summary Data
    Lin, Zhaotong
    Xue, Haoran
    Pan, Wei
    GENETIC EPIDEMIOLOGY, 2022, 46 (07) : 511 - 511
  • [26] Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics
    Morrison, Jean
    Knoblauch, Nicholas
    Marcus, Joseph H.
    Stephens, Matthew
    He, Xin
    NATURE GENETICS, 2020, 52 (07) : 740 - +
  • [27] A robust two-sample transcriptome-wide Mendelian randomization method integrating GWAS with multi-tissue eQTL summary statistics
    Gleason, Kevin J.
    Yang, Fan
    Chen, Lin S.
    GENETIC EPIDEMIOLOGY, 2021, 45 (04) : 353 - 371
  • [28] LD hub and MR-base: online platforms for preforming LD score regression and Mendelian randomization analysis using GWAS summary data
    Zheng, Jie
    Haycock, Philip
    Hemani, Gibran
    Elsworth, Benjamin
    Shihab, Hashem
    Laurin, Charles
    Erzurumluoglu, Mesut
    Howe, Laurence
    Wade, Kaitlin
    Warrington, Nicole
    Finucane, Hilary
    Price, Alkes
    Anttila, Verneri
    Paternoster, Lavinia
    Martin, Richard
    Relton, Caroline
    Gaunt, Tom
    Smith, George Davey
    Neale, Benjamin
    Evans, David
    BEHAVIOR GENETICS, 2016, 46 (06) : 815 - 815
  • [29] Using GCPBayes to explore pleiotropy at gene-level between breast and ovarian cancers based on GWAS summary statistics data
    Asgari, Yazdan
    Sugier, Pierre-Emmanuel
    Baghfalaki, Taban
    Karimi, Mojgan
    Lucotte, Elise
    Ngo, Amelie
    Severi, Gianluca
    Liquet, Benoit
    Truong, Therese
    EUROPEAN JOURNAL OF HUMAN GENETICS, 2023, 31 : 599 - 600
  • [30] Subset scanning for multi-trait analysis using GWAS summary statistics
    Cao, Rui
    Olawsky, Evan
    McFowland III, Edward
    Marcotte, Erin
    Spector, Logan
    Yang, Tianzhong
    BIOINFORMATICS, 2024, 40 (01)