Evidence of an association of leptin serum levels and craving in alcohol dependence

被引：67

作者：

Hillemacher, Thomas ^{[1
]}

Bleich, Stefan ^{[1
]}

Frieling, Helge ^{[1
]}

Schanze, Anja ^{[1
]}

Wilhelm, Julia ^{[1
]}

Sperling, Wolfgang ^{[1
]}

Kornhuber, Johannes ^{[1
]}

Kraus, Thomas ^{[1
]}

机构：

[1] Univ Erlangen Nurnberg, Dept Psychiat & Psychotherapy, D-91054 Erlangen, Germany

来源：

PSYCHONEUROENDOCRINOLOGY | 2007年 / 32卷 / 01期

关键词：

leptin; craving; alcoholism; HPA axis; OCDS; body mass index;

D O I：

10.1016/j.psyneuen.2006.09.013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recent studies have described an association of leptin serum levels and craving in alcohol dependent patients. The aim of the present study was to investigate a large patients' sample using a power-based statistical analysis. We included 156 mate and 33 female patients suffering from alcohol dependence admitted for detoxification treatment. Leptin serum levels were measured using a commercial. ELISA kit. The Obsessive Compulsive Drinking Scale (OCDS) was used to assess alcohol craving at admission. For both genders Spearman's correlation revealed significant results. These findings could be confirmed using multiple linear regression models (mates: r = 1.881, t = 4.338, p < 0.001; females: r = 6.160, t = 5.793, p < 0.001) with a power of 1.00. In contrast to previous results describing an association only in female patients, this power-based analysis shows that leptin is associated with alcohol craving in both genders. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：87 / 90

页数：4

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