pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom

被引：0

作者：

Sutherland, Colin J. ^{[1
,2
]}

Lansdell, Paul ^{[1
]}

Sanders, Mandy ^{[3
]}

Muwanguzi, Julian ^{[2
]}

van Schalkwyk, Donelly A. ^{[2
]}

Kaur, Harparkash ^{[2
]}

Nolder, Debbie ^{[1
]}

Tucker, Julie ^{[1
]}

Bennett, Hayley M. ^{[3
]}

Otto, Thomas D. ^{[3
]}

Berriman, Matthew ^{[3
]}

Patel, Trupti A. ^{[4
]}

Lynn, Roderick ^{[5
]}

Gkrania-Klotsas, Effrossyni ^{[6
]}

Chiodini, Peter L. ^{[1
,4
]}

机构：

[1] London Sch Hyg & Trop Med, Publ Hlth England Malaria Reference Lab, London, England

[2] London Sch Hyg & Trop Med, Dept Immunol & Infect, Fac Infect & Trop Dis, London, England

[3] Wellcome Trust Sanger Inst, Hinxton, England

[4] Hosp Trop Dis, London, England

[5] Cambridge Univ Hosp NHS Fdn Trust, Addenbrookes Hosp, Dept Haematol, Cambridge, England

[6] Cambridge Univ Hosp NHS Fdn Trust, Dept Infect Dis, Addenbrookes Hosp, Cambridge, England

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 03期

基金：

英国惠康基金;

关键词：

imported malaria; treatment failure; parasite genotyping; antimalarial agents; drug resistance mechanisms; UNCOMPLICATED MALARIA; ARTEMISININ; RESISTANCE;

D O I：

10.1128/AAC.02382-16

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitemia within 6 weeks of treatment with no intervening travel to countries where malaria is endemic. Parasite isolates, all of African origin, harbored variants at some candidate resistance loci. No evidence of pfk13-mediated artemisinin resistance was found. Vigilance for signs of unsatisfactory antimalarial efficacy among imported cases of malaria is recommended.

引用

页数：5

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