pfk13-Independent Treatment Failure in Four Imported Cases of Plasmodium falciparum Malaria Treated with Artemether-Lumefantrine in the United Kingdom

被引：0

作者：

Sutherland, Colin J. ^{[1
,2
]}

Lansdell, Paul ^{[1
]}

Sanders, Mandy ^{[3
]}

Muwanguzi, Julian ^{[2
]}

van Schalkwyk, Donelly A. ^{[2
]}

Kaur, Harparkash ^{[2
]}

Nolder, Debbie ^{[1
]}

Tucker, Julie ^{[1
]}

Bennett, Hayley M. ^{[3
]}

Otto, Thomas D. ^{[3
]}

Berriman, Matthew ^{[3
]}

Patel, Trupti A. ^{[4
]}

Lynn, Roderick ^{[5
]}

Gkrania-Klotsas, Effrossyni ^{[6
]}

Chiodini, Peter L. ^{[1
,4
]}

机构：

[1] London Sch Hyg & Trop Med, Publ Hlth England Malaria Reference Lab, London, England

[2] London Sch Hyg & Trop Med, Dept Immunol & Infect, Fac Infect & Trop Dis, London, England

[3] Wellcome Trust Sanger Inst, Hinxton, England

[4] Hosp Trop Dis, London, England

[5] Cambridge Univ Hosp NHS Fdn Trust, Addenbrookes Hosp, Dept Haematol, Cambridge, England

[6] Cambridge Univ Hosp NHS Fdn Trust, Dept Infect Dis, Addenbrookes Hosp, Cambridge, England

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2017年 / 61卷 / 03期

基金：

英国惠康基金;

关键词：

imported malaria; treatment failure; parasite genotyping; antimalarial agents; drug resistance mechanisms; UNCOMPLICATED MALARIA; ARTEMISININ; RESISTANCE;

D O I：

10.1128/AAC.02382-16

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We present case histories of four patients treated with artemether-lumefantrine for falciparum malaria in UK hospitals in 2015 to 2016. Each subsequently presented with recurrent symptoms and Plasmodium falciparum parasitemia within 6 weeks of treatment with no intervening travel to countries where malaria is endemic. Parasite isolates, all of African origin, harbored variants at some candidate resistance loci. No evidence of pfk13-mediated artemisinin resistance was found. Vigilance for signs of unsatisfactory antimalarial efficacy among imported cases of malaria is recommended.

引用

页数：5

共 50 条

[1] Plasmodium falciparum malaria recrudescence after treatment with artemether-lumefantrine
Bourque, Daniel L.
Chen, Lin H.
JOURNAL OF TRAVEL MEDICINE, 2020, 27 (01)
[2] First Case of Treatment Failure of Artemether-Lumefantrine in a Japanese Traveler with Imported Falciparum Malaria
Mizuno, Yasutaka
Kato, Yasuyuki
Kudo, Koichiro
Kano, Shigeyuki
JAPANESE JOURNAL OF INFECTIOUS DISEASES, 2009, 62 (02) : 139 - 141
[3] Efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Nepal
Ghimire P.
Rijal K.R.
Kafle C.
Karki B.S.
Singh N.
Ortega L.
Thakur G.D.
Adhikari B.
Tropical Diseases, Travel Medicine and Vaccines, 4 (1)
[4] Tailoring a Pediatric Formulation of Artemether-Lumefantrine for Treatment of Plasmodium falciparum Malaria
Bassat, Quique
Ogutu, Bernhards
Djimde, Abdoulaye
Stricker, Kirstin
Hamed, Kamal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2015, 59 (08) : 4366 - 4374
[5] Population Pharmacokinetics of Lumefantrine in Pregnant Women Treated with Artemether-Lumefantrine for Uncomplicated Plasmodium falciparum Malaria
Tarning, Joel
McGready, Rose
Lindegardh, Niklas
Ashley, Elizabeth A.
Pimanpanarak, Mupawjay
Kamanikom, Benjamas
Annerberg, Anna
Day, Nicholas P. J.
Stepniewska, Kasia
Singhasivanon, Pratap
White, Nicholas J.
Nosten, Francois
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2009, 53 (09) : 3837 - 3846
[6] Therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in four malaria endemic states of India
Krishna, Sri
Mishra, Sweta
Tiwari, Prakash
Vishwakarma, Anup K.
Khandai, Sushrikanta
Shrivastava, Suyesh
Verma, Anil K.
Tiwari, Shashikant
Barman, Hari
Jhariya, Surendra
Tiwari, Pradeep
Tidgam, Anup S.
Varun, Brij M.
Singh, Sunil
Yerane, Naresh
Tembhurne, Chintaman R.
Mandavi, Prem L.
Tekam, Shyam S.
Malik, Manas
Behera, Kali P.
Jayswar, Himanshu
Sonwani, Khemraj
Diggikar, Mukund S.
Pradhan, Madan M.
Khasotiya, Sher S.
Kumar, Avdhesh
Dhingra, Neeraj
Bustos, Maria Dorina G.
Christophel, Eva-Maria
Ringwald, Pascal
Kumari, Roop
Shukla, Man M.
Singh, Neeru
Das, Aparup
Bharti, Praveen K.
MALARIA JOURNAL, 2021, 20 (01)
[7] Treatment failure of Artemether-lumefantrine in Falciparum Malaria in Brazilian Amazon area
Quiroga, M.
Lara, A.
Mascheretti, M.
Abati, P.
Boulos, M.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2010, 14 : E115 - E115
[8] Therapeutic efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in four malaria endemic states of India
Sri Krishna
Sweta Mishra
Prakash Tiwari
Anup K. Vishwakarma
Sushrikanta Khandai
Suyesh Shrivastava
Anil K. Verma
Shashikant Tiwari
Hari Barman
Surendra Jhariya
Pradeep Tiwari
Anup S. Tidgam
Brij M. Varun
Sunil Singh
Naresh Yerane
Chintaman R. Tembhurne
Prem L. Mandavi
Shyam S. Tekam
Manas Malik
Kali P. Behera
Himanshu Jayswar
Khemraj Sonwani
Mukund S. Diggikar
Madan M. Pradhan
Sher S. Khasotiya
Avdhesh Kumar
Neeraj Dhingra
Maria Dorina G. Bustos
Eva-Maria Christophel
Pascal Ringwald
Roop Kumari
Man M. Shukla
Neeru Singh
Aparup Das
Praveen K. Bharti
Malaria Journal, 20
[9] EFFICACY OF ARTEMETHER-LUMEFANTRINE FOR THE TREATMENT OF UNCOMPLICATED <it>PLASMODIUM FALCIPARUM</it> MALARIA IN NORTHWEST ETHIOPIA
Bayih, Abebe
Abere, Aberham
Pillai, Dylan
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE, 2018, 99 (04): : 313 - 313
[10] Artemether-lumefantrine treatment failure of uncomplicated Plasmodium falciparum malaria in travellers coming from Angola and Mozambique
Silva-Pinto, Andre
Domingos, Joao
Cardoso, Margarida
Reis, Ana
Benavente, Ernest Diez
Caldas, Joao Paulo
Conceicao, Claudia
Toscano, Cristina
Baptista-Fernandes, Teresa
Clark, Taane G.
Mansinho, Kamal
Campino, Susana
Nogueira, Fatima
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES, 2021, 110 : 151 - 154

← 1 2 3 4 5 →