Smoking, APOE Genotype, and Cognitive Decline: The Rotterdam Study

被引：16

作者：

Wingbermuhle, Robin ^{[1
]}

Wen, Ke-xin ^{[1
]}

Wolters, Frank J. ^{[1
,2
]}

Ikram, M. Arfan ^{[1
,2
,3
]}

Bos, Daniel ^{[1
,3
]}

机构：

[1] Erasmus MC, Dept Epidemiol, Rotterdam, Netherlands

[2] Erasmus MC, Dept Neurol, Rotterdam, Netherlands

[3] Erasmus MC, Dept Radiol & Nucl Med, Rotterdam, Netherlands

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2017年 / 57卷 / 04期

关键词：

APOE epsilon 4 genotype; cognitive decline; epidemiology; smoking; CARDIOVASCULAR RISK; ALZHEIMERS-DISEASE; DEMENTIA; METAANALYSIS; CESSATION; MORTALITY;

D O I：

10.3233/JAD-170063

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The association of smoking with preclinical cognitive decline remains unclear and may be modified by the APOE epsilon 4 genotype. In 5,705 participants (mean age: 63.9 +/- 9.1 years; 57.4% women) from the population-based Rotterdam Study, we investigated the relationship between smoking and cognitive decline over a 5.5-year period and examined potential effect modification by APOE epsilon 4 genotype. We found that current smoking was related to decline in global cognition [ difference compared to never smoking: -0.06 (95% C.I.-0.10;-0.01)],as well as decline on specific cognitive tests including the Letter Digit Substitution Task, the 15-Word Learning Test, and the Purdue Pegboard. We found no evidence for effect modification by APOE epsilon 4 genotype on this relation.

引用

页码：1191 / 1195

页数：5

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