A Possible New Diagnostic Biomarker in Early Diagnosis of Alzheimer's Disease

被引:23
|
作者
Kork, Felix [2 ,3 ]
Holthues, Jan [4 ]
Hellweg, Rainer [5 ]
Jankowski, Vera [1 ,6 ]
Tepel, Martin [1 ,6 ]
Oehring, Renate [7 ]
Heuser, Isabella [8 ]
Bierbrauer, Jeffrey [2 ,3 ]
Peters, Oliver [8 ]
Schlattmann, Peter [9 ]
Zidek, Walter [1 ,6 ]
Jankowski, Joachim [1 ,6 ]
机构
[1] Charite Campus Benjamin Franklin, Med Klin 4, D-12200 Berlin, Germany
[2] Charite, Dept Anesthesiol & Intens Care Med, Campus Virchow Klinikum, D-13353 Berlin, Germany
[3] Campus Charite Mitte, Berlin, Germany
[4] Jewish Hosp, Dept Psychiat & Psychotherapy, Berlin, Germany
[5] Charite, Campus Charite Mitte, Dept Psychiat & Psychotherapy, D-13353 Berlin, Germany
[6] Charite, Med Klin 4, Campus Benjamin Franklin, Berlin, Germany
[7] Dept Neurol, Potsdam, Germany
[8] Charite, Campus Benjamin Franklin, Dept Psychiat & Psychotherapy, D-13353 Berlin, Germany
[9] Charite, Dept Biometry & Med Stat, D-13353 Berlin, Germany
关键词
Alzheimer disease; NMR spectroscopy; diagnostic marker; biomarker; cerebrospinal fluid; metabonomics; NEUROPSYCHOLOGICAL ASSESSMENT; DEMENTIA; MARKERS; CONSORTIUM; ESTABLISH; REGISTRY; CERAD; PREDICTION; SERUM; AGE;
D O I
10.2174/156720509790147160
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Early diagnosis in patients with Alzheimer's disease (AD) is of great importance since only a sufficient treatment in early stages of this disease helps to keep patients in an autonomous state for as long as possible. Until now, there is no single diagnostic biomarker for AD derived from material routinely obtained. In this study, proton nuclear magnetic resonance (H-1-NMR) spectra of the cerebrospinal fluid (CSF) of AD patients were compared with H-1-NMR spectra of the CSF of healthy control subjects using a metabonomic approach. The H-1-NMR spectra of CSF of AD patients showed specific multipletts at 2.15 ppm and 2.45 ppm, which could not be detected in the majority (59.3% and 70.4%, respectively) of healthy control subjects (positive likelihood ratio (+LR) 2.33, 95% CI [1.46, 3.72], p<0.01; + LR 3.22, 95% CI [1.78, 5.78], p<0.01). Moreover, CSF H-1-NMR spectra of AD patients showed specific resonances at 7.03 ppm (+ LR 3.38, 95% CI [1.60, 7.14], p<0.05), 7.19 ppm (+LR 2.89, 95% CI [1.46, 5.74], p<0.05), 7.43 ppm (+LR 3.15, 95% CI [1.47, 6.75], p< 0.05), and at 7.91 ppm (+ LR 3.38, 95% CI [1.60, 7.14], p<0.01). CSF H-1-NMR spectroscopy is obviously a capable method for detection and quantification of substances in the CSF of AD patients even without the knowledge of molecular structures. These substances can be used as a biomarker in the early diagnosis of AD. We assume that this biomarker will simplify the diagnosis of AD, especially in early stages of the disease.
引用
收藏
页码:519 / 524
页数:6
相关论文
共 50 条
  • [31] Increased central auditory gain in 5xFAD Alzheimer's disease mice as an early biomarker candidate for Alzheimer's disease diagnosis
    Na, Daxiang
    Zhang, Jingyuan
    Beaulac, Holly J.
    Piekna-Przybylska, Dorota
    Nicklas, Paige R.
    Kiernan, Amy E.
    White, Patricia M.
    FRONTIERS IN NEUROSCIENCE, 2023, 17
  • [32] The Clinical Role of PET Imaging Biomarker in Diagnosis of Early Onset Alzheimer's Disease Dementia
    Hameed, Shahul
    Syed, Wahab
    JOURNAL OF NEUROPSYCHIATRY AND CLINICAL NEUROSCIENCES, 2019, 31 (03) : E13 - E13
  • [33] Serum sirtuin1: a potential blood biomarker for early diagnosis of Alzheimer's disease
    Wang, Jia
    Zhou, Fang
    Xiong, Chang-E
    Wang, Gui-Ping
    Chen, Lin-Wanyue
    Zhang, Yu -Tong
    Qi, Shi-Ge
    Wang, Zhi-Hui
    Mei, Can
    Xu, Yu-Jia
    Zhan, Jian-Bo
    Cheng, Jing
    AGING-US, 2023, 15 (18): : 9464 - 9478
  • [34] Synaptic vesicle glycoprotein 2 A in serum is an ideal biomarker for early diagnosis of Alzheimer's disease
    Wang, Xiaoling
    Zhang, Xiaomin
    Liu, Jing
    Zhang, Jingjing
    Liu, Congcong
    Cui, Yuting
    Song, Qiao
    Hou, Yuli
    Wang, Yaqi
    Zhang, Qian
    Zhang, Yingzhen
    Fan, Yujian
    Jia, Jianping
    Wang, Peichang
    ALZHEIMERS RESEARCH & THERAPY, 2024, 16 (01)
  • [35] Early diagnosis of Alzheimer's Disease.
    O'Brien, JT
    INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2002, 17 (03) : 293 - 293
  • [36] Early diagnosis of Alzheimer's disease and pupillometry
    Fotiou, D
    Tsalamas, C
    Rizos, G
    Goulis, C
    Polimenakou, EI
    Argiropoulos, E
    Goulas, A
    Fotiou, F
    INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, 2004, 54 (1-2) : 115 - 116
  • [37] Neurobiological early diagnosis of Alzheimer's disease
    Hampel, H.
    Teipel, S. J.
    Buerger, K.
    NERVENARZT, 2007, 78 (11): : 1310 - +
  • [38] The revealment of the early Alzheimer's disease diagnosis
    Charazac, PM
    Galice, I
    ANNALES MEDICO-PSYCHOLOGIQUES, 2000, 158 (02): : 162 - 165
  • [39] Alzheimer's disease: early diagnosis and treatment
    Chu, L. W.
    HONG KONG MEDICAL JOURNAL, 2012, 18 (03) : 228 - 237
  • [40] fMRI in the diagnosis of early Alzheimer's disease
    Machulda, MM
    Ward, HA
    Borowski, BJ
    Knopman, D
    Boeve, BF
    Petersen, RC
    Jack, CR
    NEUROLOGY, 2002, 58 (07) : A400 - A400