Catalyst-free synthesis of α-thioacrylic acids via cascade thiolation and 1,4-aryl migration of aryl alkynoates at room temperature

被引：20

作者：

Wei, Wei ^{[1
,2
,3
,4
]}

Wang, Leilei ^{[4
]}

Yue, Huilan ^{[2
,3
]}

Jiang, Yuan-Ye ^{[4
]}

Yang, Daoshan ^{[1
,4
]}

机构：

[1] Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, State Key Lab Base Ecochem Engn, Qingdao 266042, Shandong, Peoples R China

[2] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China

[3] Qinghai Prov Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China

[4] Qufu Normal Univ, Sch Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 37期

基金：

中国国家自然科学基金;

关键词：

SULFINIC ACIDS; ACTIVATED ALKYNES; OXIDATIVE DIFUNCTIONALIZATION; DIRECT HYDROSULFONYLATION; RADICAL CYCLIZATION; SELECTIVE SYNTHESIS; TERMINAL ALKYNES; VINYL SULFIDES; BOND FORMATION; ALKENES;

D O I：

10.1039/c8ob01349g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A simple and facile catalyst-free method for the construction of alpha-thioacrylic acids has been developed from readily-available aryl alkynoates and thiols at room temperature. Various alpha-thioacrylic acids could be conveniently and efficiently obtained in moderate to good yields via cascade thiolation and 1,4-aryl migration of aryl alkynoates in the absence of any catalyst and additive.

引用

页码：8379 / 8383

页数：5

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