Catalyst-free synthesis of α-thioacrylic acids via cascade thiolation and 1,4-aryl migration of aryl alkynoates at room temperature

被引：20
|
作者：
Wei, Wei [1 ,2 ,3 ,4 ]
Wang, Leilei [4 ]
Yue, Huilan [2 ,3 ]
Jiang, Yuan-Ye [4 ]
Yang, Daoshan [1 ,4 ]
机构：
[1] Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, State Key Lab Base Ecochem Engn, Qingdao 266042, Shandong, Peoples R China
[2] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China
[3] Qinghai Prov Key Lab Tibetan Med Res, Xining 810008, Qinghai, Peoples R China
[4] Qufu Normal Univ, Sch Chem & Chem Engn, Qufu 273165, Shandong, Peoples R China
来源：
ORGANIC & BIOMOLECULAR CHEMISTRY | 2018年 / 16卷 / 37期
基金：
中国国家自然科学基金;
关键词：
SULFINIC ACIDS; ACTIVATED ALKYNES; OXIDATIVE DIFUNCTIONALIZATION; DIRECT HYDROSULFONYLATION; RADICAL CYCLIZATION; SELECTIVE SYNTHESIS; TERMINAL ALKYNES; VINYL SULFIDES; BOND FORMATION; ALKENES;
D O I：
10.1039/c8ob01349g
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple and facile catalyst-free method for the construction of alpha-thioacrylic acids has been developed from readily-available aryl alkynoates and thiols at room temperature. Various alpha-thioacrylic acids could be conveniently and efficiently obtained in moderate to good yields via cascade thiolation and 1,4-aryl migration of aryl alkynoates in the absence of any catalyst and additive.
引用
收藏
页码：8379 / 8383
页数：5
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