A new preparative synthesis of 1-D-6-O-(2-amino-2-deoxy-D-glycopyranosyl)-chiro-inositol 1-phosphate and 1,2-cyclic phosphate

被引：0

作者：

Martín-Lomas, M ^{[1
]}

Flores-Mosquera, M ^{[1
]}

Khiar, N ^{[1
]}

机构：

[1] USE, CSIC, Inst Invest Quim, Grp Carbohidratos, Seville 41092, Spain

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2000年 / 2000卷 / 08期

关键词：

inositolphosphoglycans; oligosaccharide synthesis; insulin mediators;

D O I：

10.1002/(SICI)1099-0690(200004)2000:8<1539::AID-EJOC1539>3.0.CO;2-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient preparative synthesis of 1-D-6-O-(2-amino-2-deoxy-alpha-D-glycopyranosyl)-chiro-inositol 1-phosphate (III) and -1,2-cyclic phosphate (IV) using D-chiro-inositol as starting material is reported. Compound III has been previously found to behave as type P inositolphosphoglycans (the putative second messengers of insulin-like growth factor I) in organotypic cultures of chicken embryo. The synthesis of III and IV, now reported, considerably improves previous synthesis of III and permits the effective preparation of these substances for biological investigation.

引用

页码：1539 / 1545

页数：7

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