Progressive supranuclear palsy

被引：0

作者：

Bartosova, T. ^{[1
]}

Klempir, J. ^{[1
,2
,3
]}

机构：

[1] 1 LF UK VFN Praze, Neurol Klin, Ctr Klin Kych Neuroved, Katerinska 30, Prague 12000, Czech Republic

[2] 1 LF UK VFN Praze, Anat Ostav, Prague 12000, Czech Republic

[3] Evropska Referentni Sit Pro Vzacna Neurol, Prague, Czech Republic

来源：

CESKA A SLOVENSKA NEUROLOGIE A NEUROCHIRURGIE | 2020年 / 83卷 / 06期

关键词：

progressive supranuclear palsy; vertical gaze palsy; tauopathy; postural instability; parkinsonism; cognitive decline; levodopa; amantadine; FRONTOTEMPORAL LOBAR DEGENERATION; MAGNETIC-RESONANCE PARKINSONISM; RICHARDSON-OLSZEWSKI SYNDROME; SLEEP BEHAVIOR DISORDER; CORTICOBASAL DEGENERATION; DIFFERENTIAL-DIAGNOSIS; PHENOTYPIC SPECTRUM; DEMENTIA COMPLEX; SPINAL-CORD; TAU;

D O I：

10.48095/cccsnn2020584

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Progressive supranuclear palsy is a tauopathy belonging to atypical Parkinsonian syndromes. The main clinical symptoms include oculomotor dysfunctions, early postural instability, symmetrical hypokinetic-rigid syndrome with axial predominance and cognitive decline. The symptom variability and rate of progression depend on disease subtype. Diagnostics are based on clinical symptoms; MRI remains the most useful auxiliary method. The article is focused mainly on clinical perspectives and recent diagnostic approaches considering the latest recommendations. Symptomatic therapy remains of great importance as causal treatment is still lacking.

引用

页码：584 / 601

页数：18

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