Decreased cerebrospinal fluid levels of β-phenylethylamine in patients with Rett syndrome

被引：0

作者：

Satoi, M

Matsuishi, T

Yamada, S

Yamashita, Y

Ohtaki, E

Mori, K

Riikonen, R

Kato, H

Percy, AK

机构：

[1] Kurume Univ, Sch Med, Dept Pediat & Child Hlth, Kurume, Fukuoka 8300011, Japan

[2] Kurume Univ, Sch Med, Inst Brain Res, Kurume, Fukuoka 830, Japan

[3] Univ Tokushima, Sch Med, Dept Pediat, Tokushima 770, Japan

[4] Kuopio Univ Hosp, Dept Child Neurol, Kuopio, Finland

[5] Univ Alabama, Dept Pediat, Div Child Neurol, Birmingham, AL USA

来源：

ANNALS OF NEUROLOGY | 2000年 / 47卷 / 06期

关键词：

D O I：

10.1002/1531-8249(200006)47:6<801::AID-ANA13>3.0.CO;2-L

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To clarify the mechanism of brain impairment in Rett syndrome, we measured the cerebrospinal fluid levels of beta-phenylethylamine (PEA) in 17 patients with Rett syndrome. Findings were compared with those obtained in age-matched controls and diseased controls. The cerebrospinal fluid level of PEA was significantly lower in patients with Rett syndrome than in the controls (31% of control values). The alteration in the cerebrospinal fluid level of PEA may reflect dopamine system impairment in Rett syndrome.

引用

页码：801 / 803

页数：3

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