Accuracy of AccessBio Immunoglobulin M and Total Antibody Rapid Immunochromatographic Assays for the Diagnosis of Acute Scrub Typhus Infection

被引：34
|
作者：
Blacksell, Stuart D. [1 ,2 ,3 ]
Jenjaroen, Kemajittra [1 ]
Phetsouvanh, Rattanaphone [3 ]
Wuthiekanun, Vanaporn [1 ]
Day, Nicholas P. J. [1 ,2 ,3 ]
Newton, Paul N. [2 ,3 ]
Ching, Wei-Mei [4 ]
机构：
[1] Mahidol Univ, Fac Trop Med, Oxford Trop Med Res Unit MORU, Bangkok 10400, Thailand
[2] Univ Oxford, Ctr Trop Med, Churchill Hosp, Oxford OX3 7LJ, England
[3] Mahosot Hosp, Wellcome Trust Mahosot Hosp, Oxford Trop Med Res Collaborat, Microbiol Lab, Viangchan, Laos
[4] USN, Med Res Ctr, Viral & Rickettsial Dis Dept, Infect Dis Directorate, Silver Spring, MD USA
来源：
CLINICAL AND VACCINE IMMUNOLOGY | 2010年 / 17卷 / 02期
基金：
英国惠康基金;
关键词：
POLYMERASE-CHAIN-REACTION; RICKETTSIA-TSUTSUGAMUSHI; ORIENTIA-TSUTSUGAMUSHI; DENGUE; THAILAND; LAOS;
D O I：
10.1128/CVI.00448-08
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Using archived samples, we assessed the diagnostic capacity of a rapid immunochromatographic test (ICT) for the detection of Orientia tsutsugamushi IgM and total antibodies to aid with the diagnosis of acute scrub typhus infection in febrile patients in Laos. The sensitivity and the specificity of the ICT for the detection of IgM were 96.8% (121/125 samples; 95% confidence interval [CI], 92.1 to 99.1%) and 93.3% (98/105 samples; 95% CI, 86.7 to 97.3%), respectively. For the detection of total antibodies, the sensitivity was 97.6% (122/125 samples; 95% CI, 93.1 to 99.5%), but the specificity was much lower, at 71.4% (75/105 samples; 95% CI, 61.8 to 79.8%).
引用
收藏
页码：263 / 266
页数：4
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