Are submicroscopic chromosomal inversions predisposing factors for the t(9;22)(q34;q11.2) translocation in chronic myeloid leukemia?

被引：0

作者：

Gonzalez Garcia, Juan Ramon ^{[1
]}

Dominguez Cruz, Martin Daniel ^{[1
,2
]}

Borjas Gutierrez, Cesar ^{[1
,2
]}

机构：

[1] CIBO Inst Mexicano Seguro Social, Div Genet, Sierra Mojada 800, Guadalajara 44340, Jalisco, Mexico

[2] CUCS Univ Guadalajara, Doctorado Genet Humana, Guadalajara, Jalisco, Mexico

来源：

MOLECULAR CYTOGENETICS | 2015年 / 8卷

关键词：

Chronic myeloid leukemia; t(9; 22) translocation; Submicroscopic inversion; Duplicons; Non-allelic homologous recombination; GENE;

D O I：

10.1186/s13039-015-0116-9

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

A complex chromosomal rearrangement observed in a patient with chronic myeloid leukemia was explained as the consequence of a multistep process. The explanation involved an initial t(9;22) translocation with breakpoints distant from the BCR and ABL1 genes followed by genomic deletions that produced the BCR-ABL1 hybrid gene. We present an alternative model that fits the origin of the patient's rearrangement better. The present model links submicroscopic inversions with the occurrence of the t(9;22) translocation and opens a new approach on the research on the disease.

引用

页数：3

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