Are submicroscopic chromosomal inversions predisposing factors for the t(9;22)(q34;q11.2) translocation in chronic myeloid leukemia?

被引：0
|
作者：
Gonzalez Garcia, Juan Ramon [1 ]
Dominguez Cruz, Martin Daniel [1 ,2 ]
Borjas Gutierrez, Cesar [1 ,2 ]
机构：
[1] CIBO Inst Mexicano Seguro Social, Div Genet, Sierra Mojada 800, Guadalajara 44340, Jalisco, Mexico
[2] CUCS Univ Guadalajara, Doctorado Genet Humana, Guadalajara, Jalisco, Mexico
来源：
MOLECULAR CYTOGENETICS | 2015年 / 8卷
关键词：
Chronic myeloid leukemia; t(9; 22) translocation; Submicroscopic inversion; Duplicons; Non-allelic homologous recombination; GENE;
D O I：
10.1186/s13039-015-0116-9
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
A complex chromosomal rearrangement observed in a patient with chronic myeloid leukemia was explained as the consequence of a multistep process. The explanation involved an initial t(9;22) translocation with breakpoints distant from the BCR and ABL1 genes followed by genomic deletions that produced the BCR-ABL1 hybrid gene. We present an alternative model that fits the origin of the patient's rearrangement better. The present model links submicroscopic inversions with the occurrence of the t(9;22) translocation and opens a new approach on the research on the disease.
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页数：3
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