Does aspirin use reduce the risk for cancer?

被引：11

作者：

Iqbal, Usman ^{[1
,2
]}

Yang, Hsuan-Chia ^{[2
,3
]}

Jian, Wen-Shan ^{[2
,4
]}

Yen, Yun ^{[5
,6
]}

Li, Yu-Chuan ^{[2
,5
,7
]}

机构：

[1] Taipei Med Univ, Coll Publ Hlth, Masters Program, Global Hlth & Dev Dept, Taipei, Taiwan

[2] Int Ctr Hlth Informat Technol, Taipei, Taiwan

[3] Natl Yang Ming Univ, Inst Biomed Informat, Taipei, Taiwan

[4] Taipei Med Univ, Sch Hlth Care Adm, Coll Management, Taipei, Taiwan

[5] Taipei Med Univ, Coll Med Sci & Technol, Taipei, Taiwan

[6] City Hope Natl Med Ctr, Duarte, CA USA

[7] Wan Fang Hosp, Dept Dermatol, Taipei, Taiwan

来源：

JOURNAL OF INVESTIGATIVE MEDICINE | 2017年 / 65卷 / 02期

关键词：

Aspirin; Cancer; Drugs; Investigational; Drug-Related Side Effects and Adverse Reactions; Carcinogenesis; PREVENT COLORECTAL ADENOMAS; RANDOMIZED-TRIAL;

D O I：

10.1136/jim-2016-000275

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Recently, studies have reported that aspirin has chemopreventive properties. In this study, we used the Taiwan NHI database, which covers a population of 23 million (99.99%) Taiwanese from 2001 to 2011. This was a case-control study which identified 601,733 patients using ICD-9-CM codes who were diagnosed with cancer. Each case with 4 eligible controls was matched for age, sex, and index date and adjusted for confounding factors. The observed overall cancer risk (adjusted OR (AOR), 0.95; 95% CI 0.94 to 0.96) reduced with aspirin use, specifically, colorectal (AOR, 0.97; 95% CI 0.94 to 0.99) and digestive system (AOR, 0.96; 95% CI 0.94 to 0.98) cancers. Findings from the Asian population would contribute to the discussion on aspirin's safety profile.

引用

页码：391 / 392

页数：2

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