IGFs and IGFBPs: role in health and disease

被引：88

作者：

Monzavi, R ^{[1
]}

Cohen, P ^{[1
]}

机构：

[1] Univ Calif Los Angeles, Mattel Childrens Hosp, David Geffen Sch Med, Los Angeles, CA 90095 USA

来源：

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM | 2002年 / 16卷 / 03期

关键词：

insulin-like growth factor; insulin-like growth factor binding protein; insulin-like growth factor receptor; insulin-like growth factor binding protein protease; growth; growth hormone deficiency; growth hormone therapy;

D O I：

10.1053/beem.2002.0212

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The insulin-like growth factors (IGFs), IGF-binding proteins (IGFBPs), and IGFBP proteases are the main regulators of somatic growth and cellular proliferation. IGFs are involved in growth pre-natally and post-natally. Dysregulation of the IGF axis can lead to growth disorders such as growth hormone deficiency and acromegaly. Pre-natally, this dysregulation can lead to IUGR or macrosomia. IGFs also have an important mitogenic action and play a role in tumorigenesis and cancer. These actions are regulated by co-interactions with IGFBPs, especially IGFBP-3. In addition to somatic growth and mitogenic activity, IGFs have hypoglycaemic and insulin sensitizing actions, and their dysregulation is involved in diabetes and its complications. In this chapter, we examine the role of IGFs and IGFBPs in growth, tumorigenesis and diabetes, and discuss treatment modalities for each disease involving the GH-IGF-IGFBP axis, including discussion of current in vitro and in vivo investigations in this field.

引用

页码：433 / 447

页数：15

共 50 条

[21] Emerging concepts in the role of IGFs and cancer
LeRoith, D
HORMONE AND METABOLIC RESEARCH, 2003, 35 (11-12) : 649 - 650
[22] The interaction of insulin-like growth factors (IGFs) with insulin-like growth factor binding proteins (IGFBPs): a review
Carrick, FE
Wallace, JC
Forbes, BE
LETTERS IN PEPTIDE SCIENCE, 2001, 8 (3-5): : 147 - 153
[23] Expression of the insulin-like growth factors (IGFs) and the IGF-binding proteins (IGFBPs) in human gastric cancer cells
Yi, HK
Hwang, PH
Yang, DH
Kang, CW
Lee, DY
EUROPEAN JOURNAL OF CANCER, 2001, 37 (17) : 2257 - 2263
[24] IGFs, IGFBPs, IGF-binding sites and biochemical markers of bone metabolism during differentiation in human pulp fibroblasts
Reichenmiller, KM
Mattern, C
Ranke, MB
Elmlinger, MW
HORMONE RESEARCH, 2004, 62 (01) : 33 - 39
[25] The interaction of Insulin-like Growth Factors (IGFs) with Insulin-like Growth Factor Binding Proteins (IGFBPs): a review
Francine E. Carrick
John C. Wallace
Briony E. Forbes
Letters in Peptide Science, 2001, 8 : 147 - 153
[26] Serum levels of insulin-like growth factors (IGFs) and their binding proteins (IGFBPs),-1,-2,-3, in oral cancer
Brady, G.
O'Regan, E.
Miller, I.
Ogungbowale, A.
Kapas, S.
Crean, S. J.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 2007, 36 (03) : 259 - 262
[27] Insulin resistance and cancer: the role of insulin and IGFs
Djiogue, Sefirin
Nwabo Kamdje, Armel Herve
Vecchio, Lorella
Kipanyula, Maulilio John
Farahna, Mohammed
Aldebasi, Yousef
Etet, Paul Faustin Seke
ENDOCRINE-RELATED CANCER, 2013, 20 (01) : R1 - R17
[28] ROLE OF IGFS IN GROWTH-HORMONE HOMEOSTASIS
BERELOWITZ, M
MOLECULAR AND CELLULAR BIOLOGY OF INSULIN-LIKE GROWTH FACTORS AND THEIR RECEPTORS, 1989, : 25 - 37
[29] NUTRITIONAL INSULT AND RECOVERY IN THE NEONATAL RAT CEREBELLUM - INSULIN-LIKE GROWTH-FACTORS (IGFS) AND THEIR BINDING-PROTEINS (IGFBPS)
SHAMBAUGH, GE
NATARAJAN, N
DAVENPORT, ML
OEHLER, D
UNTERMAN, T
NEUROCHEMICAL RESEARCH, 1995, 20 (04) : 475 - 490
[30] Developmental expression of insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) in the early postnatal rat uterus.
Gu, Y
Branham, WS
Sheehan, DM
Streck, RD
BIOLOGY OF REPRODUCTION, 1997, 56 : 4 - 4

← 1 2 3 4 5 →