Synthesis and Characterization of a Novel Near-Infrared Fluorescent Probe for Living Cells Imaging

被引：0

作者：

Xing, Jing ^{[1
,2
,3
]}

Wang, Zhe ^{[4
]}

Sun, Chunlong ^{[5
]}

Ji, Min ^{[1
,2
,3
]}

机构：

[1] Southeast Univ, Sch Biol Sci & Med Engn, Nanjing 210096, Jiangsu, Peoples R China

[2] Southeast Univ, Sch Biol Sci & Med Engn, Suzhou 215123, Peoples R China

[3] Southeast Univ, Collaborat Innovat Ctr Suzhou Nano Sci & Technol, Suzhou 215123, Peoples R China

[4] Nanjing Med Univ, Affiliated Hosp 2, Emergency Dept, Nanjing 210029, Jiangsu, Peoples R China

[5] Binzhou Univ, Coll Life Sci, Binzhou 256600, Peoples R China

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2020年 / 20卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Near-Infrared Fluorescence Imaging; Human Lung Adenocarcinoma Epithelial Cell Line; Fluorescent Probe; lndocyanine Green; IR789; CONTRAST AGENTS; DYES; DOTS;

D O I：

10.1166/jnn.2020.16942

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Currently, optical probes with near-infrared (NIR) fluorescence are of great interest in chemical biology. In the present study, we designed and synthesized a novel NIR fluorescent probe, IR789. IR789 has high selectivity and sensitivity for living cells imaging. The stronger excitation and emission characteristics suggested its dominant optical properties over ICG. IR789 also showed a high affinity and inconspicuous cytotoxicity at the cellular level. The results of fluorescent image in living A549 cells (human lung adenocarcinoma epithelial cell line) further demonstrated its potential applications for biomedical diagnosis in biological systems utilization of nanotechnology.

引用

页码：668 / 672

页数：5

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