Synthesis of glycyrrhizic acid conjugates containing L-lysine

被引：9
|
作者：
Baltina, L. A., Jr.
Kondratenko, R. M.
Baltina, L. A.
Plyasunova, O. A.
Galin, F. Z.
Tolstikov, G. A.
机构：
[1] Russian Acad Sci, Inst Organ Chem, Ufa Sci Ctr, Ufa 450054, Russia
[2] Bashkir State Med Univ, Ufa 450000, Russia
[3] Vector State Sci Ctr Virol & Biotechnol, Novosibirsk 633159, Koltsovo, Russia
[4] Russian Acad Sci, Novosibirsk Organ Chem Inst, Siberian Div, Novosibirsk 630090, Russia
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2006年 / 42卷 / 05期
关键词：
glycyrrhizic acid; L-lysine;
D O I：
10.1007/s10600-006-0210-7
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Activated esters and N-hydroxybenzotriazole-N,N'-dicyclohexylcarbodiimide (DCC) or N-hydroxysuccinimide-DCC were used to synthesize conjugates of glycyrrhizic acid (GA) with N-epsilon-carbobenzyloxy-L-lysine [Lys(Z)-OH] and its esters containing two or three amino components. It was shown that the conjugate of GA 30-methyl ester with Lys(Z)-OH possessed anti-HIV-1 activity.
引用
收藏
页码：543 / 548
页数：6
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