Synthesis of glycyrrhizic acid conjugates containing L-lysine

被引：9

作者：

Baltina, L. A., Jr.

Kondratenko, R. M.

Baltina, L. A.

Plyasunova, O. A.

Galin, F. Z.

Tolstikov, G. A.

机构：

[1] Russian Acad Sci, Inst Organ Chem, Ufa Sci Ctr, Ufa 450054, Russia

[2] Bashkir State Med Univ, Ufa 450000, Russia

[3] Vector State Sci Ctr Virol & Biotechnol, Novosibirsk 633159, Koltsovo, Russia

[4] Russian Acad Sci, Novosibirsk Organ Chem Inst, Siberian Div, Novosibirsk 630090, Russia

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2006年 / 42卷 / 05期

关键词：

glycyrrhizic acid; L-lysine;

D O I：

10.1007/s10600-006-0210-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Activated esters and N-hydroxybenzotriazole-N,N'-dicyclohexylcarbodiimide (DCC) or N-hydroxysuccinimide-DCC were used to synthesize conjugates of glycyrrhizic acid (GA) with N-epsilon-carbobenzyloxy-L-lysine [Lys(Z)-OH] and its esters containing two or three amino components. It was shown that the conjugate of GA 30-methyl ester with Lys(Z)-OH possessed anti-HIV-1 activity.

引用

页码：543 / 548

页数：6

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