DNA Repair Gene XRCC1 Polymorphisms and Outcome of Renal Cell Carcinoma in Caucasian Patients

被引：0
|
作者：
Bachmann, Hagen S. [1 ]
Ruebben, Herbert [2 ]
Schmid, Kurt W. [3 ]
Siffert, Winfried [1 ]
Riemann, Kathrin [1 ]
机构：
[1] Univ Hosp Essen, Inst Pharmacogenet, D-45147 Essen, Germany
[2] Univ Hosp Essen, Dept Urol, D-45147 Essen, Germany
[3] Univ Hosp Essen, Inst Pathol & Neuropathol, D-45147 Essen, Germany
来源：
ANTICANCER RESEARCH | 2009年 / 29卷 / 12期
关键词：
DNA repair; genetic polymorphism; haplotype; renal cell cancer; outcome; XRCC1; LUNG-CANCER PATIENTS; SURVIVAL; ASSOCIATION; FREQUENCY; ADDUCTS; RISK; XPD;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Background: The human X-ray repair cross-complementing group 1 (XRCC1) enzyme plays an important role in response to DNA damage. Two common polymorphisms in XRCC1, Arg194Trp and Arg399Gln, have been repeatedly associated with risk for and outcome of numerous types of cancer treated with radio- and chemotherapy. Recently, a Japanese study suggested these polymorphisms both as risk factors and outcome predictors in renal cell carcinoma (RCC). Patients and Methods: lit the present study, 142 Caucasian patients suffering from RCC were genotyped and analyzed for tumor-related and overall survival and time to metastasis and progression. Results: Analyses revealed absence of the pre-described risk haplotype (194Trp/399Gln) as well as a lack of a statistically significant difference between the different endpoints and genotypes and diplotypes, respectively. Conclusion: We conclude that in Caucasian patients, XRCC1 polymorphisms do not influence the outcome of RCC.
引用
收藏
页码：5131 / 5135
页数：5
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