The Complexity of the cGAS-STING Pathway in CNS Pathologies

被引：32
|
作者：
Fryer, Amelia L. [1 ]
Abdullah, Amar [1 ]
Taylor, Juliet M. [1 ]
Crack, Peter J. [1 ]
机构：
[1] Univ Melbourne, Neuropharmacol Lab, Dept Pharmacol & Therapeut, Melbourne, Vic, Australia
来源：
FRONTIERS IN NEUROSCIENCE | 2021年 / 15卷
基金：
澳大利亚国家健康与医学研究理事会;
关键词：
STING; neuroinflammation; interferon; central nervous system; cGAS;
D O I：
10.3389/fnins.2021.621501
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Neuroinflammation driven by type-I interferons in the CNS is well established to exacerbate the progression of many CNS pathologies both acute and chronic. The role of adaptor protein Stimulator of Interferon Genes (STING) is increasingly appreciated to instigate type-I IFN-mediated neuroinflammation. As an upstream regulator of type-I IFNs, STING modulation presents a novel therapeutic opportunity to mediate inflammation in the CNS. This review will detail the current knowledge of protective and detrimental STING activity in acute and chronic CNS pathologies and the current therapeutic avenues being explored.
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页数：11
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