This article concerns the development of the Vector Field Orientation - Active Disturbance Rejection (VFO-ADR) cascaded path-following controller for underactuated vehicles moving in a 3-dimensional space. The proposed concept of a cascaded control structure decouples system kinematics from system dynamics, resembling the approach utilized for nonholonomic systems. Thanks to the use of an ADR control approach in the dynamic-level controller, the proposed control structure is robust to even significant model uncertainties and external disturbances. Application of an error-based form of the Extended State Observer (ESO), implemented within the ADR inner-loop controller, implies the output-feedback characteristic of the control structure, i.e., only position and attitude of the vehicle body are expected to be measured. The kinematic-level controller is designed according to the VFO method utilizing the non-parametrized path representation to calculate the commanded velocities. The description of the proposed control structure is followed by the theoretical analysis utilizing the Input-to-State Stability (ISS) theorem and the simulation verification of the proposed solution. (C) 2020 The Authors. Published by Elsevier Ltd on behalf of European Control Association.