Influence of selected variables on fabrication of Triamcinolone acetonide loaded solid lipid nanoparticles for topical treatment of dermal disorders

被引：50
|
作者：
Pradhan, Madhulika [1 ]
Singh, Deependra [1 ]
Singh, Manju Rawat [1 ]
机构：
[1] Pt Ravishankar Shukla Univ, Univ Inst Pharm, Pharmaceut Biotechnol Lab, Raipur 492010, Chhattisgarh, India
来源：
ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY | 2016年 / 44卷 / 01期
关键词：
corticosteroid; dermal disorders; process variables; psoriasis; solid lipid nanoparticles; triamcinolone acetonide; DRUG-DELIVERY; CARRIERS; SKIN; FORMULATION; NANOCARRIERS; PENETRATION; STABILITY; MELOXICAM; PSORIASIS; RELEASE;
D O I：
10.3109/21691401.2014.955105
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Aim of the study was to develop solid lipid nanoparticles (SLN) of triamcinolone acetonide (TA) and to study the effect of various process variables in order to optimize the formulation for effective delivery. Drug loaded SLNs were successfully prepared and characterized by TEM, XRD and DSC study. Process variables like surfactant concentration, drug concentration, lipid concentration etc. showed significant effect on the particle size and entrapment efficiency. SLNs exhibited prolonged drug release following Higuchi release kinetics (R-2 = 0.9909). In vitro skin distribution study demonstrated systemic escape of drug from TA loaded SLNs which might eliminate side effects associated with systemic exposure.
引用
收藏
页码：392 / 400
页数：9
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