Ruthenium-Catalyzed PIII-Directed Remote ε-C-H Alkylation of Phosphines

被引：20
|
作者：
Xu, Hui-Bei [1 ,2 ]
Chen, Yin-Jun [2 ]
Chai, Xin-Yue [2 ]
Yang, Jia-Hui [2 ]
Xu, Yan-Jun [1 ]
Dong, Lin [2 ]
机构：
[1] Sichuan Normal Univ, Coll Chem & Mat Sci, Chengdu 610066, Sichuan, Peoples R China
[2] Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst Educ, Chengdu 610041, Peoples R China
来源：
ORGANIC LETTERS | 2021年 / 23卷 / 06期
关键词：
D O I：
10.1021/acs.orglett.0c03906
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The ruthenium-catalyzed remote epsilon-C-H alkylation of phosphines with tertiary alkyl halides has been developed. This novel P-III-directed C-H activation strategy tolerated various functional groups and delivered a wide variety of modified phosphines with excellent meta-site selectivity. Preliminary mechanistic studies indicated that a P-III-assisted ortho-cyclometalation/remote sigma-activation pathway might be involved in this methodology.
引用
收藏
页码：2052 / 2056
页数：5
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