DIFFERENTIAL c-FOS EXPRESSION IN NUCLEI OF THE CAUDAL MEDULLA OBLONGATA FOLLOWING NOXIOUS COLORECTAL DISTENSION IN ANAESTHETIZED RATS

被引:0
|
作者
Lyubashina, Olga [1 ]
Atanasova, Dimitrinka [2 ]
Panteleev, Sergey [1 ]
Itzev, Dimitar [2 ]
Lazarov, Nikolai [2 ,3 ]
机构
[1] Russian Acad Sci, IP Pavlov Physiol Inst, Lab Cort Visceral Physiol, St Petersburg 199034, Russia
[2] Bulgarian Acad Sci, Inst Neurobiol, BU-1113 Sofia, Bulgaria
[3] Med Univ Sofia, Fac Med, Dept Anat & Histol, Sofia 1431, Bulgaria
来源
COMPTES RENDUS DE L ACADEMIE BULGARE DES SCIENCES | 2012年 / 65卷 / 05期
基金
俄罗斯基础研究基金会;
关键词
caudal medulla; c-Fos expression; colorectal distension; spinal visceral afferents; visceral pain; rat; LATERAL SPINAL-CORD; VISCERAL PAIN; CLINICAL-ASPECTS; DORSAL COLUMN; NEURONS; PATHWAY; INPUT; BRAIN; AREA;
D O I
暂无
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
It has been suggested that noxious information from the lower bowel may reach the medulla oblongata via several spinal pathways terminating in the ventrolateral reticular area, the nuclei of the solitary tract and medullar dorsal column nuclei correspondingly. The contribution of these pathways to visceral pain processing in the medulla is not established. In this study, performed in urethane-anaesthetized rats, we used c-Fos immunohistochemistry to quantitatively characterize and compare neuronal responses in the gracile (Gr) and cuneate (Cu) nuclei, nuclei of the solitary tract (NTS), lateral reticular nucleus (LRt) and ventrolateral reticular area (VLM) of the medulla to a repeated noxious colorectal distension (CRD). When compared with sham distension, after CRD, the most pronounced induction of c-Fos expression was observed in the NTS, while a modest increase was found in the Gr. Simultaneously, the CRD produced a distinct decrease in the c-Fos immunoreactivity in the VLM. Changes in the c-Fos expression observed in Cu and LRt were insignificant. The present results suggest that under anaesthesia the transmission of nociceptive information from the colorectal region to the medulla is mainly accomplished via excitatory spinosolitary afferents and ventrolateral spinal pathway recruiting inhibitory mechanisms in the medullar reticular formation. The excitatory spinal inputs to the dorsal column nuclei seem to be modestly involved.
引用
收藏
页码:709 / 716
页数:8
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