Synthesis of new spin labels for Cu-free click conjugation

被引：25

作者：

Kalai, Tamas ^{[1
]}

Fleissner, Mark R. ^{[2
]}

Jeko, Jozsef ^{[3
]}

Hubbell, Wayne L. ^{[2
]}

Hideg, Kalman ^{[1
]}

机构：

[1] Univ Pecs, Dept Organ & Med Chem, H-7602 Pecs, Hungary

[2] UCLA Sch Med, Jules Stein Eye Inst, Los Angeles, CA 90095 USA

[3] Coll Nyiregyhaza, Dept Chem, H-4440 Nyiregyhaza, Hungary

来源：

TETRAHEDRON LETTERS | 2011年 / 52卷 / 21期

基金：

美国国家卫生研究院;

关键词：

Amino acids; Acetylenes; Click chemistry; Free radicals; Spin labeling; CHEMISTRY; NITROXYLS;

D O I：

10.1016/j.tetlet.2011.03.077

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

New pyrroline nitroxides attached to a terminal acetylenic sulfone, a dibenzocyclooctyne or a cyclooctyne carboxylic acid were synthesized and tested in Cu-free click reactions to conjugate these new spin labels with 4-azido-TEMPO, azidophenylalanine and an azidophenylalanine-containing protein. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：2747 / 2749

页数：3

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