We present a novel surface plasmon resonance (SPR) sensor based on serial organization of sensing channels and sequential spectral encoding of responses from sensing channels into an optical spectrum. This approach allows probing interfacial processes by surface plasmons of different field profiles which makes it possible to distinguish surface and bulk contributions to SPR sensor response. We illustrate this unique feature of the presented approach in a model biosensing experiment in which the detection of human chorigonadotropin (hCG) is compensated for background refractive index interference.
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Natl Inst Adv Ind Sci & Technol, Hlth & Med Res Inst, Tsukuba, Ibaraki 3058566, JapanNatl Inst Adv Ind Sci & Technol, Hlth & Med Res Inst, Tsukuba, Ibaraki 3058566, Japan
Sugai, Hiroka
Tomita, Shunsuke
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Natl Inst Adv Ind Sci & Technol, Hlth & Med Res Inst & DAILAB, DBT AIST Int Ctr Translat & Environm Res DAICtr, Tsukuba, Ibaraki 3058566, JapanNatl Inst Adv Ind Sci & Technol, Hlth & Med Res Inst, Tsukuba, Ibaraki 3058566, Japan
Tomita, Shunsuke
Ishihara, Sayaka
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Natl Inst Adv Ind Sci & Technol, Hlth & Med Res Inst, Tsukuba, Ibaraki 3058566, JapanNatl Inst Adv Ind Sci & Technol, Hlth & Med Res Inst, Tsukuba, Ibaraki 3058566, Japan
Ishihara, Sayaka
Yoshioka, Kyoko
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Natl Inst Adv Ind Sci & Technol, Hlth & Med Res Inst, Tsukuba, Ibaraki 3058566, JapanNatl Inst Adv Ind Sci & Technol, Hlth & Med Res Inst, Tsukuba, Ibaraki 3058566, Japan